Preisler Livia, Samara Nivin, Kalma Yael, Arad Tali, Groutz Asnat, Azem Foad, Amir Hadar
Racine IVF Unit, Affiliated to the Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Fertility Institute, Lis Maternity Hospital, Tel Aviv University, 6 Weizmann Street, Tel Aviv, Israel.
J Relig Health. 2025 Feb;64(1):124-147. doi: 10.1007/s10943-024-02200-7. Epub 2024 Dec 9.
On September 5, 2010, the Israeli Parliament passed a law that allows Israeli female residents to donate their oocytes to infertile Israeli female residents. This law includes unique restrictions that do not exist in other countries. Our aim was to characterize Israeli oocyte donors and recipients and the outcomes of the oocyte donation program as regulated by national law. This retrospective study included 26 financially compensated volunteer donors (mean age 29 ± 3.52 years) and 69 recipients (mean age 44.6 ± 3.53 years) who underwent 30 intracytoplasmic sperm injection cycles and 166 embryo transfers (ETs) in our unit between March 2016 and November 2020. Stringent legal caveats unique to Israel (e.g., Jewish/Moslem donor only to Jewish/Moslem recipient, only unmarried donor, eggs in one cycle restricted to ≤ 3 recipients, donated sperm only from non-Jewish donors, and more) were meticulously applied. Sociodemographic characterizations of donors and recipients were reviewed, and pregnancy and obstetric outcomes were determined. Variables that were significant in achieving live births among the recipients were examined. Twenty-five donors and all 69 recipients were Jewish, and most were unmarried and childless. The main indication for seeking egg donation was age ≥ 40 years/perimenopause (80%). One-half of the recipients used donor sperm and one-half used partner sperm. The pregnancy, clinical pregnancy, live birth, and miscarriage rates were 28.6%, 19.2%, 18.2%, and 2.8%. The live birth rate was negatively associated with multiple ETs. Maternal complications included hypertensive disorders of pregnancy (18.2%), gestational diabetes mellitus (32.3%), and caesarean sections (78.8%). There were no adverse neonatal outcomes. In conclusion, few young women are interested in donating oocytes in Israel. Pregnancy and live birth rates are lower than published values in other egg donation programs.
2010年9月5日，以色列议会通过了一项法律，允许以色列女性居民向不孕的以色列女性居民捐赠卵母细胞。这项法律包含一些其他国家不存在的独特限制。我们的目的是描述以色列卵母细胞捐赠者和接受者的特征，以及国家法律规定下卵母细胞捐赠计划的结果。这项回顾性研究纳入了26名获得经济补偿的志愿捐赠者（平均年龄29±3.52岁）和69名接受者（平均年龄44.6±3.53岁），他们于2016年3月至2020年11月在我们单位接受了30个卵胞浆内单精子注射周期和166次胚胎移植（ET）。以色列特有的严格法律规定（例如，犹太/穆斯林捐赠者只能捐赠给犹太/穆斯林接受者，仅未婚捐赠者可捐赠，一个周期的卵子限于≤3名接受者，仅接受非犹太捐赠者的捐赠精子等）得到了严格执行。对捐赠者和接受者的社会人口学特征进行了审查，并确定了妊娠和产科结局。研究了在接受者中实现活产的显著变量。25名捐赠者和所有69名接受者都是犹太人，大多数未婚且无子女。寻求卵子捐赠的主要指征是年龄≥40岁/围绝经期（80%）。一半的接受者使用捐赠者精子，一半使用伴侣精子。妊娠率、临床妊娠率、活产率和流产率分别为28.6%、19.2%、18.2%和2.8%。活产率与多次胚胎移植呈负相关。孕产妇并发症包括妊娠高血压疾病（18.2%）、妊娠期糖尿病（32.3%）和剖宫产（78.8%）。未出现不良新生儿结局。总之，在以色列很少有年轻女性对捐赠卵母细胞感兴趣。妊娠率和活产率低于其他卵子捐赠计划公布的值。
