Gülsunay İlayda Esna, Altunay İlknur, Kum Tuğba, Çerman Aslı Aksu
University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Dermatology Department, Seyrantepe, İstanbul, Turkey.
University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Biochemistry Department, Seyrantepe, İstanbul, Turkey.
Dermatol Pract Concept. 2024 Oct 30;14(4):e2024266. doi: 10.5826/dpc.1404a266.
In recent years, there has been a growing emphasis on the role of the mammalian target of rapamycin (mTOR) pathway in the pathogenesis of psoriasis. This intracellular signaling pathway is known as the main control pathway of metabolism and is of particular interest in this context.
To investigate the importance of the mTOR pathway in the pathogenesis of plaque psoriasis.
A total of forty patients with plaque psoriasis and 40 non-psoriatic volunteers were included in this case-control study. The fasting serum levels of mTORC1 and mTORC2 in the study groups were examined by enzyme-linked immunosorbent assay.
Serum levels of both mTORC1 and mTORC2 were found to be significantly lower in patients with plaque psoriasis than in controls (P = 0.001). A positive correlation was identified between serum mTORC1 and serum mTORC2 levels in patients with plaque psoriasis (p=0.001, r=0.826).
The lower serum levels of mTORC1 and mTORC2 complexes, which are active signaling molecules in the cell, were observed in patients with plaque psoriasis. This suggests that these levels may serve as an indicator of increased intracellular activation of these molecules. It is our opinion that agents that can effectively inhibit both mTOR complexes may be more effective in the treatment of psoriasis.
近年来，哺乳动物雷帕霉素靶蛋白（mTOR）通路在银屑病发病机制中的作用受到越来越多的关注。这条细胞内信号通路是已知的主要代谢控制通路，在这种情况下尤其受到关注。
研究mTOR通路在斑块状银屑病发病机制中的重要性。
本病例对照研究共纳入40例斑块状银屑病患者和40名非银屑病志愿者。通过酶联免疫吸附测定法检测研究组中mTORC1和mTORC2的空腹血清水平。
发现斑块状银屑病患者的mTORC1和mTORC2血清水平均显著低于对照组（P = 0.001）。斑块状银屑病患者血清mTORC1和血清mTORC2水平之间存在正相关（p = 0.001，r = 0.826）。
在斑块状银屑病患者中观察到细胞中活性信号分子mTORC1和mTORC2复合物的血清水平较低。这表明这些水平可能作为这些分子细胞内活化增加的指标。我们认为，能够有效抑制这两种mTOR复合物的药物可能在银屑病治疗中更有效。
