Wang Juan, Cui Baiping, Chen Zhongjian, Ding Xiaolei
Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, China.
Front Cell Dev Biol. 2022 Jul 22;10:950973. doi: 10.3389/fcell.2022.950973. eCollection 2022.
The epidermis, the outmost layer of the skin, is a stratified squamous epithelium that protects the body from the external world. The epidermis and its appendages need constantly renew themselves and replace the damaged tissues caused by environmental assaults. The mechanistic target of rapamycin (mTOR) signaling is a central controller of cell growth and metabolism that plays a critical role in development, homeostasis and diseases. Recent findings suggest that mTOR signaling is activated in a spatiotemporal and context-dependent manner in the epidermis, coordinating diverse skin homeostatic processes. Dysregulation of mTOR signaling underlies the pathogenesis of skin diseases, including psoriasis and skin cancer. In this review, we discuss the role of epidermal mTOR signaling activity and function in skin, with a focus on skin barrier formation, hair regeneration, wound repair, as well as skin pathological disorders. We propose that fine-tuned control of mTOR signaling is essential for epidermal structural and functional integrity.
表皮是皮肤的最外层，是一种复层鳞状上皮，可保护身体免受外界侵害。表皮及其附属器需要不断自我更新，以替换因环境侵害而受损的组织。雷帕霉素的作用靶点（mTOR）信号通路是细胞生长和代谢的核心调控因子，在发育、稳态和疾病中起关键作用。最近的研究发现表明，mTOR信号通路在表皮中以时空和背景依赖的方式被激活，协调多种皮肤稳态过程。mTOR信号通路失调是包括银屑病和皮肤癌在内的皮肤病发病机制的基础。在本综述中，我们讨论了表皮mTOR信号通路在皮肤中的活性和功能作用，重点关注皮肤屏障形成、毛发再生、伤口修复以及皮肤病理紊乱。我们提出，对mTOR信号通路进行精细调控对于表皮的结构和功能完整性至关重要。
