Sadati Maryam Sadat, Alesana Fateme, Hekmat Maryam, Parvizi Mohammad Mahdi
Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Dermatol Pract Concept. 2024 Oct 30;14(4):e2024242. doi: 10.5826/dpc.1404a242.
Seborrheic dermatitis manifests as greasy itchy lesions commonly affecting sebum-rich areas like the scalp and face. Its prevalence is 11.6% in the general population, with various internal and environmental factors contributing to its development.
This study aimed to compare the efficacy of rosemary extract lotion in the treatment of seborrheic dermatitis in comparison with topical 2% ketoconazole lotion.
This double-blind randomized controlled clinical trial included 42 patients with scalp seborrheic dermatitis, divided into rosemary lotion and ketoconazole lotion groups. Both lotions were applied twice daily for two months. The severity of scalp dandruff was assessed using the Adherent Scalp Flaking Score (ASFS). The itchiness of the scalp and quality of life were assessed using itchy quant and the Dermatology Life Quality Index (DLQI), respectively. Stata software version 14.2 was applied for statistical analysis.
The reduction in ASFS score was statistically significant in patients in the ketoconazole group in comparison with the patients in the rosemary group (P = 0.011). However, the reduction in itching score was statistically significant more in the rosemary group at the end of the first and second months in comparison with the ketoconazole group (P < 0.001). The statistical analysis demonstrated no significant difference in the reduction of DLQI scores between the rosemary and ketoconazole groups at the end of one and two months after stating the treatment in both crude and adjustment with base-line score analysis.
Both rosemary and ketoconazole lotions were effective in treating scalp seborrheic dermatitis and in decreasing patients' DLQI score.
脂溢性皮炎表现为油腻性瘙痒性皮损，常见于头皮和面部等富含皮脂的部位。其在普通人群中的患病率为11.6%，多种内在和环境因素促使其发病。
本研究旨在比较迷迭香提取物洗剂与外用2%酮康唑洗剂治疗脂溢性皮炎的疗效。
这项双盲随机对照临床试验纳入了42例头皮脂溢性皮炎患者，分为迷迭香洗剂组和酮康唑洗剂组。两种洗剂均每日涂抹两次，持续两个月。使用头皮鳞屑附着评分（ASFS）评估头皮头皮屑的严重程度。分别使用瘙痒量化评分和皮肤病生活质量指数（DLQI）评估头皮瘙痒程度和生活质量。应用Stata软件版本14.2进行统计分析。
与迷迭香组患者相比，酮康唑组患者的ASFS评分降低具有统计学意义（P = 0.011）。然而，在第一个月和第二个月末，与酮康唑组相比，迷迭香组的瘙痒评分降低在统计学上更显著（P < 0.001）。统计分析表明，在治疗开始后1个月和2个月结束时，迷迭香组和酮康唑组在DLQI评分降低方面，无论是原始分析还是经基线评分调整后的分析，均无显著差异。
迷迭香洗剂和酮康唑洗剂在治疗头皮脂溢性皮炎及降低患者DLQI评分方面均有效。
