Mustarichie Resmi, Rostinawati Tina, Pitaloka Dian Ayu Eka, Saptarini Nyi Mekar, Iskandar Yoppi
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Clin Cosmet Investig Dermatol. 2022 Nov 7;15:2391-2405. doi: 10.2147/CCID.S376700. eCollection 2022.
Seborrhea dermatitis is a skin disorder that usually appears on parts of the body that have high density of sebaceous glands, such as the face, chest, and scalp. Clinical manifestations that generally appear as scaly skin and erythema. Seborrhea dermatitis is also known as one of the causes of alopecia. Treatments that can be used for seborrhea dermatitis are antifungal, anti-inflammatory, keratolytic, and coal tar. There are concerns about poor adherence, resistance, and some side effects of drugs that have been used in the treatment of seborrhea dermatitis. Concerns regarding these issues increase the urgency for the development of new therapeutic agents in the treatment of seborrhea dermatitis. Research on medicinal plants has enormous potential to produce compounds with new structures and bioactivity. This review discusses clinical and in vitro studies related to the activity of several medicinal plants that have potential as a treatment for seborrhea dermatitis, as well as the compounds that play a role in these activities. Literature searches were carried out on the PubMed, Taylor & Francis, and SpringerLink databases using Boolean Operators to get 25 articles that match the keywords used. Of the 25 articles, six were clinical trials, while 19 were in vitro studies of Malassezia. Several plants have potential as promising therapeutic agents for the treatment of seborrhea dermatitis by inhibiting the growth of Malassezia, decreasing sebum secretion, and decreasing symptoms associated with seborrhea dermatitis such as itching, pain or burning sensation, and redness.
脂溢性皮炎是一种皮肤疾病，通常出现在皮脂腺密度高的身体部位，如面部、胸部和头皮。临床表现一般为皮肤脱屑和红斑。脂溢性皮炎也被认为是脱发的原因之一。可用于治疗脂溢性皮炎的方法有抗真菌、抗炎、角质溶解和使用煤焦油。人们担心用于治疗脂溢性皮炎的药物依从性差、产生耐药性以及存在一些副作用。对这些问题的担忧增加了开发治疗脂溢性皮炎新治疗药物的紧迫性。对药用植物的研究具有产生具有新结构和生物活性化合物的巨大潜力。本综述讨论了与几种有潜力治疗脂溢性皮炎的药用植物活性相关的临床和体外研究，以及在这些活性中起作用的化合物。使用布尔运算符在PubMed、Taylor & Francis和SpringerLink数据库中进行文献检索，以获取25篇与所用关键词匹配的文章。在这25篇文章中，6篇是临床试验，19篇是马拉色菌的体外研究。几种植物有潜力成为治疗脂溢性皮炎的有前景的治疗药物，通过抑制马拉色菌的生长、减少皮脂分泌以及减轻与脂溢性皮炎相关的症状，如瘙痒、疼痛或烧灼感以及发红。
