Takagi Yutaka, Ning Xuanhe, Takahashi Akihiko, Ishizaki Chiaki, Nishizaka Takahiro, Kaizu Kazuhiro, Miyaki Masahiro, Yamamuro Hotaka, Kawashima Makoto
Skin Care Product Research, Kao Corporation, Tokyo, Japan.
Ebisu Skin Research Center, Inforward, Inc., Tokyo, Japan.
Clin Cosmet Investig Dermatol. 2018 Apr 6;11:141-148. doi: 10.2147/CCID.S158428. eCollection 2018.
Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases.
Thirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects). After 4 weeks of daily treatment with a pseudo-ceramide and eucalyptus extract-containing lotion, the skin symptoms had significantly improved in all patients with those skin diseases.
Skin dryness, scaling, and erythema were significantly improved by treatment with the lotion. The moisture-retention ability of the scalp was significantly increased and itchiness, evaluated using a visual analog scale, decreased significantly. Accompanying those improvements was a significant improvement in the quality of life of the subjects, evaluated by the Skindex-16.
From these results, we conclude that this pseudo-ceramide and eucalyptus extract-containing lotion effectively improved the dry and scaly conditions of the scalp as well as the quality of life of subjects with atopic dermatitis, seborrheic dermatitis, or pityriasis capitis.
特应性皮炎、脂溢性皮炎和/或头皮糠疹患者的头皮常出现干燥、脱屑情况。这些头皮损害通常表现出低屏障功能和神经酰胺水平降低。因此,开展了一项临床研究,以评估局部应用含假神经酰胺和桉叶提取物的洗剂对皮肤病患者头皮的疗效。
34名受试者参与了本研究(特应性皮炎:19名受试者;脂溢性皮炎:6名受试者;头皮糠疹:9名受试者)。在用含假神经酰胺和桉叶提取物的洗剂每日治疗4周后,所有患有这些皮肤病的患者皮肤症状均有显著改善。
洗剂治疗可显著改善皮肤干燥、脱屑和红斑情况。头皮的保湿能力显著增强,使用视觉模拟量表评估的瘙痒感显著降低。伴随这些改善,通过Skindex-16评估的受试者生活质量也有显著提高。
从这些结果来看,我们得出结论,这种含假神经酰胺和桉叶提取物的洗剂有效改善了头皮的干燥和脱屑情况以及特应性皮炎、脂溢性皮炎或头皮糠疹患者的生活质量。