Felix Oghenemaro Enwa, Uthirapathy Subasini, Nathiya Deepak, Kaur Parjinder, Ravi Kumar M, Verma Ashish
Delta State University, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, PMB 1, Abraka, Delta State, Nigeria.
Faculty of Pharmacy, Pharmacology Department, Tishk International University, Erbil, Kurdistan Region, Iraq.
Gene. 2025 Feb 10;937:149153. doi: 10.1016/j.gene.2024.149153. Epub 2024 Dec 7.
Glutaminyl-peptide cyclotransferase-like protein (QPCTL) is a newly discovered enzyme that has sparked interest owing to its possible role in cancer genesis and progression. Initially discovered as a post-translational modification regulator of protein maturation, QPCTL has emerged as a key participant in cancer biology. Recent research has linked QPCTL to numerous essential cancer-related processes, including cell proliferation, migration, invasion, and apoptosis. Furthermore, QPCTL expression changes have been seen in a variety of cancer types, underlining its potential as a diagnostic and prognostic marker. The molecular mechanisms behind QPCTL's participation in cancer will be examined in this review. We investigate its involvement in the control of signaling pathways and the modification of cellular activities that are important in cancer. We also examine the clinical importance of QPCTL, including as its relationship with tumor development, metastasis, and response to treatment. We also discuss the possible therapeutic implications of targeting QPCTL in cancer therapy. QPCTL is a prospective target for the development of innovative anticancer treatments due to its participation in several cancer-associated pathways.
谷氨酰胺基肽环转移酶样蛋白（QPCTL）是一种新发现的酶，因其在癌症发生和发展中可能发挥的作用而引发了人们的兴趣。QPCTL最初被发现是蛋白质成熟的翻译后修饰调节因子，现已成为癌症生物学中的关键参与者。最近的研究将QPCTL与许多重要的癌症相关过程联系起来，包括细胞增殖、迁移、侵袭和凋亡。此外，在多种癌症类型中都观察到了QPCTL表达的变化，这突出了其作为诊断和预后标志物的潜力。本综述将探讨QPCTL参与癌症的分子机制。我们研究其在信号通路控制以及对癌症中重要的细胞活动修饰方面的作用。我们还将研究QPCTL的临床重要性，包括其与肿瘤发展、转移和治疗反应的关系。我们还将讨论在癌症治疗中靶向QPCTL可能的治疗意义。由于QPCTL参与了多种癌症相关途径，它是开发创新抗癌治疗方法的一个潜在靶点。
