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J Med Chem. 2025 Jan 23;68(2):929-943. doi: 10.1021/acs.jmedchem.4c02247. Epub 2025 Jan 2.
3
Role of glutaminyl-peptide cyclo-transferase-like protein (QPCTL) in cancer: From molecular mechanisms to immunotherapy.谷氨酰胺基肽环转移酶样蛋白（QPCTL）在癌症中的作用：从分子机制到免疫治疗
Gene. 2025 Feb 10;937:149153. doi: 10.1016/j.gene.2024.149153. Epub 2024 Dec 7.
4
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5
How chemokines organize the tumour microenvironment.趋化因子如何组织肿瘤微环境。
Nat Rev Cancer. 2024 Jan;24(1):28-50. doi: 10.1038/s41568-023-00635-w. Epub 2023 Dec 8.
6
Therapeutic potential of glutaminyl cyclases: Current status and emerging trends.谷氨酰胺环化酶的治疗潜力：现状与新趋势
Drug Discov Today. 2023 Oct;28(10):103644. doi: 10.1016/j.drudis.2023.103644. Epub 2023 May 26.

新型哌啶基吡啶基甲腈衍生物作为治疗癌症的QPCT和QPCTL抑制剂

Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer.

作者信息

Sabnis Ram W

机构信息

Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Atlanta, Georgia 30309, United States.

出版信息

ACS Med Chem Lett. 2025 Apr 2;16(4):540-541. doi: 10.1021/acsmedchemlett.5c00142. eCollection 2025 Apr 10.

DOI:10.1021/acsmedchemlett.5c00142
PMID:40236558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995225/
Abstract

Provided herein are novel piperidinylpyridinylcarbonitrile derivatives as QPCT and QPCTL inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds.

摘要

本文提供了作为QPCT和QPCTL抑制剂的新型哌啶基吡啶基甲腈衍生物、药物组合物、此类化合物在治疗癌症中的用途以及制备此类化合物的方法。