Feraru Alexandra, Tóth Zsejke-Réka, Magyari Klára, Baia Monica, Gyulavári Tamás, Páll Emőke, Licarete Emilia, Costinas Codrut, Cadar Oana, Papuc Ionel, Baia Lucian
Doctoral School of Physics, Babes-Bolyai University, M. Kogălniceanu 1, 400084 Cluj-Napoca, Romania; Nanostructured Materials and Bio-Nano-Interfaces Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, T. Laurian 42, 400271 Cluj-Napoca, Romania.
Nanostructured Materials and Bio-Nano-Interfaces Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, T. Laurian 42, 400271 Cluj-Napoca, Romania.
Int J Biol Macromol. 2025 Feb;288:138569. doi: 10.1016/j.ijbiomac.2024.138569. Epub 2024 Dec 7.
Medical practice has proven that chronic wounds can be treated successfully if the dressing is chosen according to the healing phase of the wound. Correct intervention from the hemostasis and inflammatory phase can prevent oxidative stress and ensure optimal conditions for healing. It is important to design a new wound dressing that does not cause additional injury, has an antioxidant effect, removes dead cells, and promotes wound healing. Considering that the traditional dressings are not moisture-retentive, we proposed an alginate-gum arabic polymeric matrix enhanced with cerium oxide nanoparticles. The cryogels were prepared by cross-linking polysaccharides and cerium oxide nanoparticles via calcium cations to form a sponge-like structure. The blend of micro- and macro-pores provides a suitable environment for nutrient distribution and keeps an adequate moisture level, mimicking the functions of the native cellular matrix. The release of cerium oxide nanoparticles occurs gradually, at the same time as the degradation of the biopolymer, promoting the attachment and viability of keratinocytes and fibroblast cells. It was found that stimulating epithelial regeneration is improved through the antioxidant effect and the adsorption capacity of hemoglobin. The results also indicate good in vitro biocompatibility and recommend them as promising dressings for skin wound treatments.
医学实践证明，如果根据伤口的愈合阶段选择敷料，慢性伤口可以得到成功治疗。在止血和炎症阶段进行正确干预可以防止氧化应激，并确保愈合的最佳条件。设计一种不会造成额外损伤、具有抗氧化作用、能清除死细胞并促进伤口愈合的新型伤口敷料非常重要。考虑到传统敷料不具有保湿性，我们提出了一种用氧化铈纳米颗粒增强的海藻酸钠-阿拉伯胶聚合物基质。通过钙阳离子使多糖和氧化铈纳米颗粒交联制备冷冻凝胶，形成海绵状结构。微孔和大孔的混合为营养物质分布提供了合适的环境，并保持适当的水分水平，模拟天然细胞基质的功能。氧化铈纳米颗粒的释放与生物聚合物的降解同时逐渐发生，促进角质形成细胞和成纤维细胞的附着和活力。研究发现，通过抗氧化作用和血红蛋白的吸附能力可改善上皮再生。结果还表明其具有良好的体外生物相容性，并推荐它们作为皮肤伤口治疗的有前景的敷料。
