College of Physics, Sichuan University, Chengdu 610065, China; Faculty of Information Engineering and Automation, Kunming University of Science and Technology, Kunming 650031, China.
College of Physics, Sichuan University, Chengdu 610065, China.
Int J Biol Macromol. 2024 Nov;280(Pt 4):135722. doi: 10.1016/j.ijbiomac.2024.135722. Epub 2024 Sep 17.
The challenge remains in developing hemostatic dressings that can fulfill both hemostatic and repair functions to meet clinical demands worldwide. Herein, the biodegradable powders composed of benzeneboronic acid-modified sodium alginate/catechol-modified quaternized chitosan hydrogel (SBQCC) networks and bioactive cerium oxide nanoparticles (CNPs), were prepared for hemostasis and promoting wound healing. The SBQCC/CNPs powders had good self-gelation ability, water absorption ratio, tissue adhesiveness and biocompatibility. The SBQCC/CNPs powders could not only rapidly absorb a large amount of blood to concentrate coagulation factors when applied on bleeding wounds, but also formed an adhesive hydrogel physical barrier to control bleeding in situ. Meanwhile, the aggregation and activation of red blood cells and platelets induced by the SBQCC/CNPs powders can initiate the forming of internal blood clot with fibrin to further enhance the hemostatic effect. The SBQCC/CNPs powders demonstrated excellent hemostatic performance in non-compressible rat tail vein bleeding and rabbit liver bleeding models. In addition, SBQCC/CNPs powder-derived hydrogels had antibacterial activity and multiple biological activities, including antioxidant, anti-inflammatory and promoting angiogenesis for accelerating wound healing. Therefore, the SBQCC/CNPs powders can accelerate wound healing while achieving effective hemostasis, which will be a promising hemostatic dressing.
开发既能满足止血需求又能满足修复功能的止血敷料以满足全球临床需求仍然是一个挑战。在此，我们制备了由苯硼酸改性海藻酸钠/儿茶酚改性季铵化壳聚糖水凝胶（SBQCC）网络和生物活性氧化铈纳米粒子（CNPs）组成的可生物降解粉末，用于止血和促进伤口愈合。SBQCC/CNPs 粉末具有良好的自凝胶能力、吸水率、组织粘附性和生物相容性。SBQCC/CNPs 粉末不仅可以在出血伤口上迅速吸收大量血液以浓缩凝血因子，而且可以形成粘性水凝胶物理屏障，就地控制出血。同时，SBQCC/CNPs 粉末诱导的红细胞和血小板聚集和激活可以引发纤维蛋白形成内部血栓，从而进一步增强止血效果。SBQCC/CNPs 粉末在不可压缩的大鼠尾静脉出血和兔肝出血模型中表现出优异的止血性能。此外，SBQCC/CNPs 粉末衍生的水凝胶具有抗菌活性和多种生物活性，包括抗氧化、抗炎和促进血管生成，以加速伤口愈合。因此，SBQCC/CNPs 粉末可以在有效止血的同时加速伤口愈合，有望成为一种理想的止血敷料。
