Nie Xiaojuan, Xu Lanlan, Wang Qingwu, Ding Xu, Xu Xiaodong, Shi Qiang, Li Junqing
Key Laboratory of Superlight Materials & Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
ACS Appl Mater Interfaces. 2025 Jan 8;17(1):297-310. doi: 10.1021/acsami.4c14837. Epub 2024 Dec 16.
Current wound dressings are insufficient in simultaneously addressing bacterial infections and oxidative stress, which severely affects wound healing outcomes. To solve this problem, we introduced poly(ionic liquid) (PIL) with strong antibacterial properties and cerium oxide nanoparticles (CeONPs) with excellent antioxidant capabilities into polyacrylonitrile (PAN) nanofiber membranes to prepare a novel composite dressing. The PIL-CeONPs-PAN nanofiber membrane provides sustained antibacterial activity through stably embedded PIL, while the uniformly distributed CeONPs achieve controlled release, avoiding safety issues caused by the rapid release of active substances. In vitro and in vivo experiments demonstrated that the membrane exhibits outstanding biocompatibility, significant antibacterial effects (inhibition rates of 88.3% against and 93.2% against ), and excellent antioxidant performance (64.7% reactive oxygen species scavenging rate). More importantly, PIL-CeONPs-PAN achieved a 94.1% wound healing rate within 14 days, significantly superior to traditional treatment methods. The results indicate that this composite membrane significantly improves wound healing by simultaneously resisting infection and oxidative stress, providing a safe and effective new option for clinical applications. Our work offers an innovative design strategy that combines antibacterial and antioxidant mechanisms for wound care.
目前的伤口敷料在同时解决细菌感染和氧化应激方面存在不足，这严重影响伤口愈合效果。为了解决这个问题，我们将具有强大抗菌性能的聚离子液体（PIL）和具有出色抗氧化能力的氧化铈纳米颗粒（CeONPs）引入聚丙烯腈（PAN）纳米纤维膜中，制备了一种新型复合敷料。PIL-CeONPs-PAN纳米纤维膜通过稳定嵌入的PIL提供持续的抗菌活性，而均匀分布的CeONPs实现控释，避免了活性物质快速释放引起的安全问题。体外和体内实验表明，该膜表现出出色的生物相容性、显著的抗菌效果（对[具体细菌1]的抑制率为88.3%，对[具体细菌2]的抑制率为93.2%）和优异的抗氧化性能（活性氧清除率为64.7%）。更重要的是，PIL-CeONPs-PAN在14天内实现了94.1%的伤口愈合率，明显优于传统治疗方法。结果表明，这种复合膜通过同时抵抗感染和氧化应激显著改善了伤口愈合，为临床应用提供了一种安全有效的新选择。我们的工作提供了一种将抗菌和抗氧化机制相结合用于伤口护理的创新设计策略。
