Feng Jing, Cen Qiuyu, Cui Yanru, Hu Xiaomin, Li Min, Wang Linjie, Wei Juanfang, Sun Nianyi, Wang Junyu, Zhang Anren
Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, China.
Pharmacol Res. 2025 Jan;211:107541. doi: 10.1016/j.phrs.2024.107541. Epub 2024 Dec 7.
Depression, a complex psychological disorder, involves multiple biological pathways in its pathogenesis. In recent years, the gut-brain axis theory has provided novel insights into the pathogenesis of depression, particularly the crucial role of the gut microbiota in mood regulation. While there remains no universal consensus on the most efficacious strains for depression treatment, Lactobacillus rhamnosus has risen to prominence within the realm of probiotics for its potential to positively modulate depressive symptoms. This review preliminarily explores the clinical significance of Lactobacillus rhamnosus in the treatment of depression and summarizes the potential mechanisms by which Lactobacillus rhamnosus treats depression, including its regulation of gut microbiota, alterations in gene expression, improvement of intestinal barrier function, maintenance of neurotransmitter balance, suppression of inflammatory responses, modulation of the immune system, coping with oxidative stress, and optimization of metabolic processes. Future research needs to further explore these mechanisms and combine them with clinical research results to optimize treatment plans and provide more effective treatment options for patients with depression.
抑郁症是一种复杂的心理障碍，其发病机制涉及多种生物学途径。近年来，肠-脑轴理论为抑郁症的发病机制提供了新的见解，尤其是肠道微生物群在情绪调节中的关键作用。虽然对于治疗抑郁症最有效的菌株尚无普遍共识，但鼠李糖乳杆菌因其对抑郁症状具有积极调节作用的潜力，在益生菌领域中崭露头角。本综述初步探讨了鼠李糖乳杆菌在抑郁症治疗中的临床意义，并总结了鼠李糖乳杆菌治疗抑郁症的潜在机制，包括其对肠道微生物群的调节、基因表达的改变、肠道屏障功能的改善、神经递质平衡的维持、炎症反应的抑制、免疫系统的调节、应对氧化应激以及代谢过程的优化。未来的研究需要进一步探索这些机制，并将其与临床研究结果相结合，以优化治疗方案，为抑郁症患者提供更有效的治疗选择。
