Mahdei Nasir Mahalleh Nima, Hemmati Mina, Biyabani Arezou, Pirouz Fatemeh
Department of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
DNA Cell Biol. 2025 Feb;44(2):55-81. doi: 10.1089/dna.2024.0170. Epub 2024 Dec 9.
Breast cancer (BC) is a significant contributor to cancer-related deaths in women, and it has complex connections with obesity and aging. This review explores the interaction between obesity and aging in relation to the development and progression of BC, focusing on the controlling role of microRNAs (miRNAs). Obesity, characterized by excess adipose tissue, contributes to a proinflammatory environment and metabolic dysregulation, which are important in tumor development. Aging, associated with cellular senescence and systemic changes, further exacerbates these conditions. miRNAs, small noncoding RNAs that regulate gene expression, play key roles in these processes, impacting pathways involved in cell proliferation, apoptosis, and cancer metastasis, either as tumor suppressors or oncogenes. Importantly, specific miRNAs are implicated in mediating the impact of obesity and aging on BC. Exploring the regulatory networks controlled by miRNAs provides valuable information on new targets for therapy and predictive markers, demonstrating the potential for using miRNA-based interventions to treat BC in obese and elderly individuals. This review emphasizes the importance of integrated research strategies to understand the complex connections between obesity, aging, and miRNA regulation in BC.
乳腺癌（BC）是导致女性癌症相关死亡的重要因素，并且它与肥胖和衰老有着复杂的联系。本综述探讨肥胖与衰老在BC发生发展过程中的相互作用，重点关注微小RNA（miRNA）的调控作用。肥胖以脂肪组织过多为特征，会导致促炎环境和代谢失调，而这在肿瘤发展过程中至关重要。衰老与细胞衰老和全身变化相关，会进一步加剧这些情况。miRNA是调节基因表达的小型非编码RNA，在这些过程中发挥关键作用，作为肿瘤抑制因子或癌基因影响细胞增殖、凋亡和癌症转移等相关通路。重要的是，特定的miRNA参与介导肥胖和衰老对BC的影响。探索由miRNA控制的调控网络可为治疗新靶点和预测标志物提供有价值的信息，这表明基于miRNA的干预措施在治疗肥胖和老年个体的BC方面具有潜力。本综述强调了综合研究策略对于理解BC中肥胖、衰老和miRNA调控之间复杂联系的重要性。
