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药物性缺血性阴茎异常勃起的评估与病因学

The assessment and aetiology of drug-induced ischaemic priapism.

作者信息

Moodley Divyen, Badenhorst Anja, Choonara Yahya, Adam Ahmed

机构信息

Department of Urology, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.

Chair and Head of Pharmacy and Pharmacology, South African DSI-NRF, Research Chair of Pharmaceutical Biomaterials, Drug Delivery and Nanomedicine, Johannesburg, South Africa.

出版信息

Int J Impot Res. 2024 Dec 9. doi: 10.1038/s41443-024-01006-1.

DOI:10.1038/s41443-024-01006-1
PMID:39653776
Abstract

Ischaemic priapism is a urological emergency characterised by a prolonged, painful erection unrelated to sexual stimulation. While several aetiological factors contribute to this condition, the pharmacological causes have gained significant attention in recent years. This narrative review aims to comprehensively assess ischaemic priapism, specifically focusing on its pharmacological aetiology. We propose an approach and assessment strategy to the numerous factors associated with pharmacologically induced ischaemic priapism. By enhancing our understanding of the pharmacological causes of this condition, healthcare professionals can improve patient management and reduce the long-term complications associated with ischaemic priapism.

摘要

缺血性阴茎异常勃起是一种泌尿外科急症,其特征为长时间的、与性刺激无关的疼痛性勃起。虽然有多种病因导致这种情况,但近年来药物性病因受到了极大关注。本叙述性综述旨在全面评估缺血性阴茎异常勃起,特别关注其药物性病因。我们针对与药物诱导的缺血性阴茎异常勃起相关的众多因素提出了一种方法和评估策略。通过加深对这种情况的药物性病因的理解,医疗保健专业人员可以改善患者管理并减少与缺血性阴茎异常勃起相关的长期并发症。

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本文引用的文献

1
Oral phosphodiesterase type 5 inhibitors and priapism: A VigiBase analysis.口服磷酸二酯酶 5 抑制剂与阴茎异常勃起:一项 VigiBase 分析。
Pharmacoepidemiol Drug Saf. 2024 Jan;33(1):e5721. doi: 10.1002/pds.5721. Epub 2023 Nov 1.
2
Adverse reactions of PDE5 inhibitors: An analysis of the World Health Organization pharmacovigilance database.PDE5 抑制剂的不良反应:世界卫生组织药物警戒数据库分析。
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Propofol-Associated Priapism.丙泊酚相关性阴茎异常勃起
Am J Ther. 2023;30(6):e589-e591. doi: 10.1097/MJT.0000000000001537. Epub 2022 Nov 17.
4
Lamotrigine induced priapism in children: case analysis and literature review.拉莫三嗪致儿童阴茎异常勃起:病例分析及文献复习。
J Int Med Res. 2022 Nov;50(11):3000605221133988. doi: 10.1177/03000605221133988.
5
Medications mostly associated with priapism events: assessment of the 2015-2020 Food and Drug Administration (FDA) pharmacovigilance database entries.与阴茎异常勃起事件相关的药物:对 2015-2020 年食品和药物管理局(FDA)药物警戒数据库条目的评估。
Int J Impot Res. 2024 Feb;36(1):50-54. doi: 10.1038/s41443-022-00583-3. Epub 2022 May 21.
6
Gabapentin-Induced Priapism.加巴喷丁诱发的阴茎异常勃起。
Cureus. 2022 Jan 14;14(1):e21241. doi: 10.7759/cureus.21241. eCollection 2022 Jan.
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Socioeconomic Disparities and Risk Factors in Patients Presenting With Ischemic Priapism: A Multi-Institutional Study.社会经济差异与缺血性阴茎异常勃起患者的风险因素:一项多机构研究。
Urology. 2022 May;163:50-55. doi: 10.1016/j.urology.2021.03.063. Epub 2021 Jul 19.
8
Recurrent Priapism From Cabergoline and Bromocriptine in a Hypogonadal Man With Prolactinoma.卡麦角林和溴隐亭引起的低促性腺激素型性腺功能减退症伴催乳素瘤患者反复发作性阴茎异常勃起
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Recurrent priapism in the setting of cannabis use.大麻使用情况下的复发性阴茎异常勃起。
J Cannabis Res. 2020 Feb 13;2(1):7. doi: 10.1186/s42238-020-0015-8.
10
Melanotan Tanning Injection: A Rare Cause of Priapism.黑素皮质素晒黑注射液:阴茎异常勃起的罕见病因。
Sex Med. 2021 Feb;9(1):100298. doi: 10.1016/j.esxm.2020.100298. Epub 2021 Jan 15.