Ma Xiaokai, Hou Junjie, Xiong Jing-Wei
Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, and College of Future Technology, Peking University, Beijing, 100871, China.
School of Basic Medical Sciences, Institute of Biomedical Innovation, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.
Cell Regen. 2024 Dec 10;13(1):29. doi: 10.1186/s13619-024-00213-x.
Cardiovascular disease is the leading cause of mortality with very limited therapeutic interventions, thus holding great hope for cardiac regenerative medicine. A recent work from Martin's laboratory reports their identification of a fetal-like cardiomyocyte progenitor, adult cardiomyocyte type 2 (aCM2), and its potential interactions with C3 cardiac fibroblasts and C3ar1 macrophages to form a regenerative cellular triad, which is only present in the regenerative heart models, YAP5SA-expressing adult hearts and neonatal hearts. The complement signaling is essential for cellular interactions in this regenerative triad. This Highlight summarizes these major findings and provides brief perspectives on the impact of this regenerative niche during cardiac regeneration in the future.
心血管疾病是导致死亡的主要原因，而治疗干预非常有限，因此心脏再生医学寄予了厚望。马丁实验室最近的一项研究报告称，他们鉴定出一种胎儿样心肌细胞祖细胞，即成年心肌细胞2型（aCM2），以及它与C3心脏成纤维细胞和C3ar1巨噬细胞之间潜在的相互作用，从而形成一个再生细胞三联体，该三联体仅存在于再生心脏模型、表达YAP5SA的成年心脏和新生心脏中。补体信号对于这个再生三联体中的细胞相互作用至关重要。本综述总结了这些主要发现，并简要展望了这个再生生态位在未来心脏再生过程中的影响。
