Furno L, Combès A, Thiébaut D, Méré A, Passade-Boupat N, Vial J
Laboratoire Sciences Analytiques, Bioanalytiques et Miniaturisation (LSABM), UMR CBI 8231 CNRS - ESPCI Paris PSL, Paris, France.
TotalEnergies, OneTech, Pôle d'Etudes et Recherche de Lacq, BP 47, Lacq, France.
J Sep Sci. 2024 Dec;47(23):e70046. doi: 10.1002/jssc.70046.
Corrosion inhibitors (CIs) are extensively employed in the oil and gas industry, yet their analysis remains a challenge. To develop a suitable liquid chromatography method for a wide array of CIs, a column screening was conducted. Nine different chromatographic conditions were tested across eight RPLC and mixed-mode columns (Accucore C18, CORTECS Shield RP18, Acquity HSS T3, Acquity Premier HSS T3, Accucore 150-C4, Accucore PFP, Synergi Polar RP, and Acclaim WCX-1). Seven model mixtures representative of CIs, which included quaternary ammoniums, imidazolines, and phosphoric esters, were considered to probe the columns. Each column exhibited unique analytical performances, peak shape, and separation profiles. To find a compromise to analyze all the mixtures with one method, Derringer desirability functions were used. Shielding of residual silanols proved to be a critical factor. The trifunctional grafting of the Acquity HSS T3 columns appeared to be a promising strategy to minimize residual silanol effects. However, it was the Premier technology, which protects the column's inner walls and frits against parasitic adsorption, which delivered the best overall results. Based on the desirability study, the Acquity Premier HSS T3 column was selected and the gradient was optimized, which enabled the separation of the molecules present in the model mixtures.
缓蚀剂（CIs）在石油和天然气工业中被广泛使用，但其分析仍然是一项挑战。为了开发一种适用于多种缓蚀剂的液相色谱方法，进行了柱筛选。在8种反相液相色谱（RPLC）柱和混合模式柱（Accucore C18、CORTECS Shield RP18、Acquity HSS T3、Acquity Premier HSS T3、Accucore 150-C4、Accucore PFP、Synergi Polar RP和Acclaim WCX-1）上测试了9种不同的色谱条件。考虑了7种代表缓蚀剂的模型混合物，其中包括季铵盐、咪唑啉和磷酸酯，以检测这些色谱柱。每种色谱柱都表现出独特的分析性能、峰形和分离谱图。为了找到一种用一种方法分析所有混合物的折衷方案，使用了Derringer合意函数。结果表明，残余硅醇的屏蔽是一个关键因素。Acquity HSS T3色谱柱的三官能团接枝似乎是一种减少残余硅醇效应的有效策略。然而，正是Premier技术保护了色谱柱的内壁和筛板免受寄生吸附，从而提供了最佳的总体结果。基于合意性研究，选择了Acquity Premier HSS T3色谱柱并优化了梯度，从而实现了模型混合物中分子的分离。
