Wang Cong, Liu Gang, Lu Qi, Ning Zhengmei, Chen Junfei
Jiangsu Research Institute of Sports Science, Nanjing, China.
Medicine (Baltimore). 2024 Dec 6;103(49):e40916. doi: 10.1097/MD.0000000000040916.
Scoliosis, marked by abnormal spinal curvature, is common in adolescents and can lead to chronic pain and reduced quality of life. The relationship between physical activity and scoliosis is debated. In this study, we aim to investigate the causal relationship between physical activity levels and idiopathic scoliosis risk using the Mendelian randomization (MR) approach. Two-sample MR analyses evaluated low-intensity (low-intensity physical activity [LIPA]), moderate-to-vigorous (MVPA), and total physical activity (TLA) as exposures, selecting genetic instruments based on their associations. Total physical activity significantly associated with idiopathic scoliosis (OR = 1.72; 95% CI = 1.11-2.68; P = .015), whereas LIPA and MVPA showed no significant associations. Reverse MR found no idiopathic scoliosis impact on activity levels. Multivariable MR showed no significant activity-scoliosis links. Total physical activity emerges as an idiopathic scoliosis risk factor, warranting mechanistic exploration. LIPA and MVPA do not causally link to scoliosis. Idiopathic scoliosis does not influence activity levels.
脊柱侧弯以脊柱异常弯曲为特征，在青少年中很常见，可导致慢性疼痛并降低生活质量。体育活动与脊柱侧弯之间的关系存在争议。在本研究中，我们旨在使用孟德尔随机化（MR）方法研究体育活动水平与特发性脊柱侧弯风险之间的因果关系。两样本MR分析将低强度（低强度体育活动[LIPA]）、中度至剧烈强度（MVPA）和总体育活动（TLA）作为暴露因素，根据其关联性选择基因工具。总体育活动与特发性脊柱侧弯显著相关（OR = 1.72；95% CI = 1.11 - 2.68；P = 0.015），而LIPA和MVPA未显示出显著关联。反向MR发现特发性脊柱侧弯对活动水平没有影响。多变量MR显示活动与脊柱侧弯之间没有显著联系。总体育活动是特发性脊柱侧弯的一个风险因素，值得进行机制探索。LIPA和MVPA与脊柱侧弯没有因果关系。特发性脊柱侧弯不影响活动水平。
