Yao Doudou, Cao Wenjuan, Liu Xiaoyan
Department of Cardiovascular Intervention Room, Wuhan Fourth Hospital, Wuhan, Hubei, China.
Medicine (Baltimore). 2024 Dec 6;103(49):e40821. doi: 10.1097/MD.0000000000040821.
To explore the clinical manifestations and factors leading to misdiagnosis in pulmonary embolism (PE) patients in a cardiology department. We retrospectively analyzed 74 patients diagnosed with PE at our hospital from March 2018 to March 2022, comparing them to 136 patients suspected of PE but excluded by computed tomography pulmonary angiography during the same period. Both groups received the same basic care, including disease counseling, nutritional planning, and monitoring. We compared general information, clinical manifestations, risk factors, and auxiliary examinations to identify correlations between specific manifestations and misdiagnosis factors. The male-to-female ratio in the PE group was approximately 3:4, which was statistically significant compared to the control group (P < .05), though its impact on PE incidence was low. Common symptoms in the PE group included chest tightness, shortness of breath, sweating, and chest pain, with no significant difference from the control group (P > .05). Notable risk factors included deep vein thrombosis (DVT) (43.24%), prolonged bed rest (32.43%), lower limb varicose veins (18.92%), trauma (21.62%), pulmonary infections (62.16%), coronary heart disease (37.84%), respiratory failure (32.43%), and chronic obstructive pulmonary disease (13.51%). DVT was significantly associated with PE (P < .05). Multivariate logistic regression identified DVT (OR = 118.528, 95% CI: 6.959-2018.906, P = .001) and lower limb varicose veins (OR = 212.766, 95% CI: 6.584-6875.950, P = .003) as independent predictive factors for suspected PE. Clinical manifestations strongly correlated with PE included pulmonary rales, cyanosis, tachycardia, hypotension, elevated D-dimer, positive N-terminal pro-brain natriuretic peptide, and sinus tachycardia on echocardiogram. PE in cardiology patients may present with pulmonary rales, hypotension, shortness of breath, and abdominal symptoms, warranting reexamination for PE. Misdiagnosis factors typically involve chest pain, tightness, and shortness of breath. Lower limb varicose veins and DVT are reliable predictors of suspected PE.
为探讨心内科肺栓塞(PE)患者的临床表现及导致误诊的因素。我们回顾性分析了2018年3月至2022年3月在我院诊断为PE的74例患者,并将其与同期136例疑似PE但经计算机断层扫描肺动脉造影排除的患者进行比较。两组均接受相同的基础护理,包括疾病咨询、营养规划和监测。我们比较了一般信息、临床表现、危险因素和辅助检查,以确定特定表现与误诊因素之间的相关性。PE组的男女比例约为3:4,与对照组相比具有统计学意义(P < .05),尽管其对PE发病率的影响较低。PE组的常见症状包括胸闷、气短、出汗和胸痛,与对照组无显著差异(P > .05)。显著的危险因素包括深静脉血栓形成(DVT)(43.24%)、长期卧床(32.43%)、下肢静脉曲张(18.92%)、创伤(21.62%)、肺部感染(62.16%)、冠心病(37.84%)、呼吸衰竭(32.43%)和慢性阻塞性肺疾病(13.51%)。DVT与PE显著相关(P < .05)。多因素logistic回归分析确定DVT(OR = 118.528,95%CI:6.959 - 2018.906,P = .001)和下肢静脉曲张(OR = 212.766,95%CI:6.584 - 6875.950,P = .003)为疑似PE的独立预测因素。与PE密切相关的临床表现包括肺部啰音、发绀、心动过速、低血压、D - 二聚体升高、N末端脑钠肽前体阳性以及超声心动图显示窦性心动过速。心内科患者的PE可能表现为肺部啰音、低血压、气短和腹部症状,需要重新检查是否为PE。误诊因素通常包括胸痛、胸闷和气短。下肢静脉曲张和DVT是疑似PE的可靠预测因素。