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经会阴开放性重建前列腺切除术后膀胱尿道吻合口狭窄后植入人工尿道括约肌。

Artificial urinary sphincter implantation after transperineal open reconstruction of post-prostatectomy vesicourethral anastomotic stenosis.

作者信息

Marks Phillip, Dahlem Roland, Fisch Margit, Schuettfort Victor M, Vetterlein Malte W, Filipas Dejan K, Ludwig Tim A

机构信息

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

Aging Male. 2025 Dec;28(1):2436862. doi: 10.1080/13685538.2024.2436862. Epub 2024 Dec 10.

Abstract

PURPOSE

This study evaluates the effectiveness of artificial urinary sphincter (AUS) implantation following transperineal reanastomosis in men with vesicourethral anastomotic stenosis (VUAS) and stress urinary incontinence (SUI) after radical prostatectomy (RP), focusing on long-term explantation rates and urinary continence.

METHODS

Patients treated between 2009 and 2020 were retrospectively analyzed. Those undergoing AUS implantation post-transperineal reanastomosis for recurrent VUAS, excluding cases with prior pelvic irradiation and overactive bladder, were included. Primary outcomes were AUS explantation rates and patient-reported continence. Median follow-up was calculated using reverse Kaplan-Meier estimates, and explantation-free survival illustrated Kaplan-Meier analyses.

RESULTS

At final follow-up, 19 patients were included at a median follow-up of 79 months. Explantation occurred in 16% ( = 3) of cases, with a median time to explantation of 107 months. No urethral erosion was observed. Explantation-free survival at 2, 5, and 10 years was 100%, 87%, and 73%, respectively. The median number of pads/day decreased significantly postoperatively, with 78% ( = 14) reporting subjective continence and 89% ( = 16) achieving social continence.

CONCLUSION

AUS implantation following transperineal reanastomosis for VUAS post-RP offers favorable long-term outcomes, with low explantation rates and no erosion, making it a viable management strategy.

摘要

目的

本研究评估经会阴再吻合术后人工尿道括约肌(AUS)植入术对根治性前列腺切除术(RP)后出现膀胱尿道吻合口狭窄(VUAS)和压力性尿失禁(SUI)男性患者的有效性,重点关注长期取出率和尿失禁情况。

方法

对2009年至2020年期间接受治疗的患者进行回顾性分析。纳入那些因复发性VUAS经会阴再吻合术后接受AUS植入术的患者,排除既往有盆腔放疗和膀胱过度活动症的病例。主要结局指标为AUS取出率和患者报告的尿失禁情况。使用反向Kaplan-Meier估计法计算中位随访时间,并通过Kaplan-Meier分析展示无取出生存率。

结果

在最终随访时,纳入了19例患者,中位随访时间为79个月。16%(n = 3)的病例发生了取出,取出的中位时间为107个月。未观察到尿道侵蚀。2年、5年和10年的无取出生存率分别为100%、87%和73%。术后每天使用尿垫的中位数显著减少,78%(n = 14)的患者报告主观上达到尿失禁,89%(n = 16)的患者实现了社会意义上的尿失禁。

结论

RP术后VUAS经会阴再吻合术后植入AUS可提供良好的长期结局,取出率低且无侵蚀,使其成为一种可行的治疗策略。

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