Aoshiba Naoya, Toriyama Kazutoshi, Yamashita Shohei, Shioiri Nao, Iwata Yuko, Uruma Tomonori, Abe Shinji, Tsushima Kenji
Department of Respiratory Medicine, Tokyo Medical University Hachioji Medical Center, 1163, Tatemachi, Hachioji-shi, Tokyo, Japan.
Department of Respiratory Medicine, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan.
Respir Med Case Rep. 2024 Nov 22;52:102141. doi: 10.1016/j.rmcr.2024.102141. eCollection 2024.
We report the case of a 76-year-old male patient with systemic sclerosis positive for anti-eukaryotic initiation factor 2B (eIF2B) antibodies. He presented to our hospital with dyspnea on exertion and, following a comprehensive physical examination, was diagnosed with interstitial lung disease associated with systemic sclerosis. Furthermore, systemic sclerosis was positive for the anti-eIF2B antibody. The presence of anti-eIF2B antibodies in systemic sclerosis is very rare, occurring in only 1-2.5 % of cases and seldom reported. Similar to our case, systemic sclerosis with positive anti-eIF2B antibodies has been reported to be more likely to be complicated by interstitial lung disease. Herein, we discuss our case in detail and summarize the previous findings.
我们报告了一例76岁男性患者，其系统性硬化症抗真核起始因子2B（eIF2B）抗体呈阳性。他因劳力性呼吸困难前来我院就诊，经过全面体格检查后，被诊断为与系统性硬化症相关的间质性肺病。此外，系统性硬化症的抗eIF2B抗体呈阳性。系统性硬化症中抗eIF2B抗体的存在非常罕见，仅在1%-2.5%的病例中出现，且鲜有报道。与我们的病例相似，抗eIF2B抗体阳性的系统性硬化症据报道更易并发间质性肺病。在此，我们详细讨论我们的病例并总结先前的研究结果。
