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基于离子液体的辣椒素刺激性防暴剂的合成、表征及刺激作用

Synthesis, characterization and irritant effects of nonivamide irritant riot control agent based on ionic liquids.

作者信息

Ma Weiting, Wang Hongying, Wang Zhenxiong, Chen Dong, Yuan Ling, Qin Liang, Mei Zongshu

机构信息

State key Laboratory of NBC Protection for Civilian, Beijing, China.

出版信息

Front Chem. 2024 Nov 25;12:1508396. doi: 10.3389/fchem.2024.1508396. eCollection 2024.

DOI:10.3389/fchem.2024.1508396
PMID:39654651
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626000/
Abstract

Active Pharmaceutical Ingredients-Ionic liquids (API-ILs) can increase drug solubility and bioavailability of solid drugs without changing the structure of drug molecules. In the present work, nonivamide (pelargonic acid vanillylamide, PAVA) was used as the active drug and choline (Ch) and citric acid (CA) were selected as the ions to prepare PAVA-based ionic liquid ([Ch][PAVA] and [PAVA] [CA]), respectively. The characterization and physical properties of [Ch][PAVA] and [PAVA] [CA], such as FT-IR spectra, 1H NMR spectra, thermal stability and hydrophilicity, were investigated. And the irritant effects of the PAVA-based ionic liquids were measured by the animal irritation experiment. [Ch][PAVA] has higher decomposition temperatures, better hydrophilicity and comparable irritant effects. The results show that the PAVA-based ILs synthesized in this study may potentially serve as a promising novel riot control agent.

摘要

活性药物成分-离子液体（API-ILs）可以在不改变药物分子结构的情况下提高固体药物的溶解度和生物利用度。在本研究中，将壬酸香草酰胺（PAVA）用作活性药物，并分别选择胆碱（Ch）和柠檬酸（CA）作为离子来制备基于PAVA的离子液体（[Ch][PAVA]和[PAVA][CA]）。研究了[Ch][PAVA]和[PAVA][CA]的表征和物理性质，如傅里叶变换红外光谱（FT-IR）、核磁共振氢谱（1H NMR）、热稳定性和亲水性。并通过动物刺激性实验测定了基于PAVA的离子液体的刺激作用。[Ch][PAVA]具有较高的分解温度、较好的亲水性和相当的刺激作用。结果表明，本研究中合成的基于PAVA的离子液体有可能成为一种有前景的新型防暴剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d09/11626000/c9edca7f88a0/fchem-12-1508396-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d09/11626000/8cf1d358e4c5/fchem-12-1508396-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d09/11626000/951e5fecfe04/fchem-12-1508396-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d09/11626000/c9edca7f88a0/fchem-12-1508396-g010.jpg

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本文引用的文献

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