Reina Bárbara Donadon, Malheiros Samuel Santana, Vieira Sâmmea Martins, Ferreira de Andrade Paula, Dovigo Lívia Nordi
Department of Social Dentistry, School of Dentistry, São Paulo State University (UNESP), R. Humaitá, 1680, Araraquara, SP, 14801-385, Brazil.
Department of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Av. Limeira, 901 - Areião, Piracicaba, SP, 13414-903, Brazil.
Heliyon. 2024 Nov 20;10(23):e40554. doi: 10.1016/j.heliyon.2024.e40554. eCollection 2024 Dec 15.
DC. (Geraniaceae) is a widely recognized medicinal plant whose natural extract exhibits therapeutic effects through a multi-target approach. Existing literature encompasses investigations of antimicrobial and cellular effects, including clinical trials. A comprehensive review is required to summary the substantial number of published investigations and to grasp the potentialities of this extract. The aim of this scoping review was to provide an overview of the antimicrobial, antiadhesive, immunomodulatory, and respiratory effects of the extract, along with a discussion of its mechanism of action, clinical safety, potential repurposing uses, and areas requiring further investigation. A systematic search of Medline (PubMED) and Scopus databases was conducted using the terms: EPs7630, , . The search process was finished on 5th, June 2024. Two researchers screened titles and abstracts according to the eligibility criteria, which included , , randomized, and non-randomized clinical trials. Out of 4367 publications identified, 134 studies were included in this review. A structured form was applied for data extraction. PRISMA-ScR was used to guide reporting of this review. Most of the studies were conducted , followed by human studies and animal models. The findings demonstrated a strong and broad-spectrum antimicrobial and antiadhesive effect against various bacterial, fungi, and virus species. Additionally, a strong immunomodulatory effect was observed, including the induction of pro-inflammatory cytokines during infection, and modulation of other immune response components. The effects on the respiratory system have been extensively examined, showing remarkable clinical efficacy against both bacterial and viral infections with no significant cytotoxicity or adverse effects. Furthermore, recent research showed an anti-COVID effect by direct antiviral and immunomodulation mechanisms. Nonetheless, the establishment of a concentration protocol to further studies is still challenging due to variations in extract origin, composition and extraction methods. In this sense, the use of a commercial extract such as EPs® 7630 is of great value to facilitate the standardization of the tested protocols. The noteworthy anti-infective potential of extract lies in its multifaceted mechanism of action, which encompasses direct microbicidal effects and modulation of the immune response. These unique properties establish extract as a promising alternative in the war against a wide range of infectious diseases.
DC.（牻牛儿苗科）是一种广为人知的药用植物，其天然提取物通过多靶点途径发挥治疗作用。现有文献涵盖了对抗菌和细胞效应的研究，包括临床试验。需要进行全面综述，以总结大量已发表的研究，并了解这种提取物的潜力。本范围综述的目的是概述该提取物的抗菌、抗黏附、免疫调节和呼吸作用，并讨论其作用机制、临床安全性、潜在的重新利用用途以及需要进一步研究的领域。使用术语“EPs7630”在Medline（PubMED）和Scopus数据库中进行了系统检索。检索过程于2024年6月5日完成。两名研究人员根据纳入标准筛选标题和摘要，纳入标准包括……、随机和非随机临床试验。在识别出的4367篇出版物中，有134项研究纳入了本综述。采用结构化表格进行数据提取。PRISMA-ScR用于指导本综述的报告。大多数研究是……进行的，其次是人体研究和动物模型。研究结果表明，该提取物对各种细菌、真菌和病毒具有强大的广谱抗菌和抗黏附作用。此外，还观察到了强大的免疫调节作用，包括在感染期间诱导促炎细胞因子，以及调节其他免疫反应成分。对呼吸系统的影响已得到广泛研究，显示出对细菌和病毒感染均具有显著的临床疗效，且无明显细胞毒性或不良反应。此外，最近的研究表明，该提取物通过直接抗病毒和免疫调节机制具有抗新冠病毒作用。然而，由于提取物来源、成分和提取方法的差异，建立进一步研究的浓度方案仍然具有挑战性。从这个意义上说，使用商业提取物如EPs® 7630对于促进测试方案的标准化具有重要价值。该提取物值得注意的抗感染潜力在于其多方面的作用机制，包括直接杀菌作用和免疫反应调节。这些独特的特性使该提取物成为对抗多种传染病的有前途的替代品。
