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磁性纳米粒子催化合成喹啉衍生物:一种绿色可持续的方法。

Magnetic nanoparticle-catalysed synthesis of quinoline derivatives: A green and sustainable method.

作者信息

Sharma Shubham, Sharma Pooja, Das D K, K Vashistha Vinod, Dhiman Jitender, Sharma Rachna, Kumar Rajesh, Singh Man Vir, Kumar Yogendra

机构信息

Department of Chemistry, Birla Institute of Higher Education, Pilani, Rajasthan, 333031, India.

Department of Chemistry, GLA University, Mathura, UP, 281406, India.

出版信息

Heliyon. 2024 Nov 20;10(23):e40451. doi: 10.1016/j.heliyon.2024.e40451. eCollection 2024 Dec 15.

Abstract

Greener and sustainable synthetic strategies have been evolving as the demanding domain of organic synthesis during the last decade. Green synthesis involves the development of method that decrease or eliminate the use of hazardous chemicals, and make use of renewable or recyclable resources. By incorporating the fundamentals and methodologies of green synthesis, organic chemists have the ability to develop valuable organic molecular frameworks which also demonstrate a strong commitment to environmental sustainability. In this context, the nanoparticle has garnered significant interest due to its various features, adhering to the principles of green synthesis. Specifically, magnetic nanoparticles have been trending extensive uses in green synthesis throughout the past decade. The role of magnetic nanoparticle has an irreplaceable place in the synthesis of biologically valuable frameworks named as quinoline. Quinoline are considered a privileged structure among organic compounds and offer a promising avenue for identifying lead structures in the search of new synthetic molecules (Saquinavir, Imiquimod and Reabamipide) having potential medicinal values and other important prospects. So, it's always indeed to the organic and medicinal chemist to develop biologically active frameworks by the green synthesis. The current manuscript consolidates the existing research on properties of environment-friendly magnetic nanoparticles for generating an extended range of valuable quinoline derivatives.

摘要

在过去十年中,更绿色、可持续的合成策略已成为有机合成领域的一个热门领域。绿色合成涉及开发减少或消除有害化学品使用,并利用可再生或可回收资源的方法。通过纳入绿色合成的基本原理和方法,有机化学家有能力开发有价值的有机分子框架,这些框架也体现了对环境可持续性的坚定承诺。在此背景下,纳米粒子因其各种特性而备受关注,符合绿色合成的原则。具体而言,在过去十年中,磁性纳米粒子在绿色合成中得到了广泛应用。磁性纳米粒子在名为喹啉的具有生物价值的框架合成中具有不可替代的作用。喹啉被认为是有机化合物中的一种特殊结构,为寻找具有潜在药用价值和其他重要前景的新合成分子(沙奎那韦、咪喹莫特和瑞巴派特)的先导结构提供了一条有前景的途径。因此,有机化学家和药物化学家通过绿色合成开发具有生物活性的框架确实一直很重要。当前的手稿总结了关于环境友好型磁性纳米粒子特性的现有研究,以生成一系列有价值的喹啉衍生物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cbc/11625306/e1cf674b41e6/ga1.jpg

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