Chen Fangsen, Chen Junhan, Liu Peitian, Huang Yanling
Department of Endocrinology and Metabolism, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
Front Nutr. 2024 Sep 25;11:1455975. doi: 10.3389/fnut.2024.1455975. eCollection 2024.
This study investigates the relationship between the Composite Dietary Antioxidant Index (CDAI) and cognitive function among elderly individuals, aiming to understand how increased antioxidant intake affects cognitive abilities in an aging population.
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, we analyzed a sample of 2,516 participants aged 60 and above. Cognitive performance was assessed using the CERAD Word Learning and Recall Test, the Animal Fluency Test, and the Digit Symbol Substitution Test. Multivariable regression models were adjusted for demographic, dietary, and health-related factors to explore the association between CDAI scores and cognitive outcomes.
The regression analyses showed a statistically significant positive association between higher CDAI scores and cognitive performance across several tests. Specifically, increments in CDAI were associated with increased scores in the CERAD Word Learning Test: Score 1 ( = 0.04, 95% CI [0.03, 0.06]), Score 2 ( = 0.04, 95% CI [0.02, 0.05]), Score 3 ( = 0.04, 95% CI [0.02, 0.06]), and the Delayed Recall Test ( = 0.04, 95% CI [0.01, 0.06]). Additionally, significant improvements were observed in the Animal Fluency Test ( = 0.19, 95% CI [0.14, 0.24]) and the Digit Symbol Test ( = 0.55, 95% CI [0.39, 0.71]). Subgroup analyses further highlighted that higher CDAI scores conferred more pronounced cognitive benefits in women, individuals aged 80 and above, Non-Hispanic Black people, and those with lower educational levels, suggesting that dietary antioxidants might be particularly beneficial in these groups.
An antioxidant-rich diet may represent a viable intervention to mitigate age-related cognitive decline, supporting cognitive health in the elderly. These results underscore the potential public health implications of dietary recommendations aimed at increasing antioxidant consumption among older adults. Further studies are necessary to confirm these findings and to investigate the underlying mechanisms in detail.
本研究调查老年人群中复合膳食抗氧化指数（CDAI）与认知功能之间的关系，旨在了解抗氧化剂摄入量增加如何影响老年人群的认知能力。
利用2011年至2014年美国国家健康与营养检查调查（NHANES）的数据，我们分析了2516名60岁及以上参与者的样本。使用CERAD词汇学习与回忆测试、动物流畅性测试和数字符号替换测试评估认知表现。多变量回归模型针对人口统计学、饮食和健康相关因素进行了调整，以探讨CDAI得分与认知结果之间的关联。
回归分析显示，在多项测试中，较高的CDAI得分与认知表现之间存在统计学上显著的正相关。具体而言，CDAI的增加与CERAD词汇学习测试中的得分增加相关：得分1（β = 0.04，95%置信区间[0.03，0.06]）、得分2（β = 0.04，95%置信区间[0.02，0.05]）、得分3（β = 0.04，95%置信区间[0.02，0.06]）以及延迟回忆测试（β = 0.04，95%置信区间[0.01，0.06]）。此外，在动物流畅性测试（β = 0.19，95%置信区间[0.14，0.24]）和数字符号测试（β = 0.55，95%置信区间[0.39，0.71]）中观察到显著改善。亚组分析进一步强调，较高的CDAI得分在女性、80岁及以上人群、非西班牙裔黑人以及教育水平较低的人群中带来更明显的认知益处，这表明膳食抗氧化剂可能对这些群体特别有益。
富含抗氧化剂的饮食可能是减轻与年龄相关的认知衰退的一种可行干预措施，有助于支持老年人的认知健康。这些结果强调了旨在增加老年人抗氧化剂摄入量的饮食建议对公共卫生的潜在影响。需要进一步的研究来证实这些发现并详细研究潜在机制。
