Ellis D L, Wheeland R G, Solomon H
J Dermatol Surg Oncol. 1985 Jan;11(1):54-9. doi: 10.1111/j.1524-4725.1985.tb02891.x.
Using a variety of techniques, estrogen and progesterone receptors have previously been identified in variable percentages of malignant melanomas. We examined 10 primary superficial spreading melanomas (SSM) with a fluorescent hormone-binding technique for estrogen and progesterone cytoplasmic receptors. Of these 6 SSM were markedly positive for estrogen and progesterone binding. Patients with dysplastic nevus syndrome (DNS) or a family history of DNS were markedly positive for estrogen and progesterone binding. A single patient with lentigo maligna and another patient with lentigo maligna melanoma were negative for estrogen and progesterone binding. None of the 21 control intradermal nevi examined for estrogen and progesterone binding exhibited marked positivity.
此前运用多种技术，已在不同比例的恶性黑色素瘤中鉴定出雌激素和孕激素受体。我们采用荧光激素结合技术，对10例原发性浅表扩散性黑色素瘤（SSM）进行了雌激素和孕激素细胞质受体检测。其中6例SSM对雌激素和孕激素结合呈明显阳性。发育异常痣综合征（DNS）患者或有DNS家族史的患者对雌激素和孕激素结合呈明显阳性。1例恶性雀斑样痣患者和另1例恶性雀斑样痣黑色素瘤患者对雌激素和孕激素结合呈阴性。所检测的21例对照皮内痣中，无一例对雌激素和孕激素结合呈明显阳性。
