Seleoglu Irem, Demirel Aynur
Department of Cardiopulmonary Rehabilitation, Faculty of Physical Therapy and Rehabilitation, University of Hacettepe, Ankara, Türkiye.
Sarcoidosis Vasc Diffuse Lung Dis. 2024 Dec 10;41(4):e2024061. doi: 10.36141/svdld.v41i4.15633.
Interstitial lung disease (ILD) is the major contributor to mortality in between chronic lung diseases. ILD originates from voluminous pathophysiological factors. One of the reasons is connective tissue diseases (CTD). According to experts, patients with CTD-ILD may have a stable disease activity and not need conventional treatment. Also, with pulmonary rehabilitation (PR), these patients may benefit from improving clinical outcomes and regression in mortality. However, the characteristics of these patients and whether they have stable disease activity in practice are not known.
The systematic review was performed via the AI-powered tool with six databases to conduct literature research. The methodologic quality of the studies, risk of bias, and level of evidence were assessed.
According to the final four included studies PR benefit moderate levels of evidence for lung functions and diffusion capacity, functional capacity, quality of life, dyspnea severity, and fatigue level. However, there was limited evidence for respiratory, and peripheral muscle strength for CTD-ILD patients.
The literature shows that the use of PR for CTD-ILDs wasn't widespread. Our findings suggest that PR can be used in CTD-ILDs to recover clinical parameters like, lung functions, quality of life, dyspnea severity, and fatigue level. More comprehensive studies should be conducted to reveal the effect of the PR in the evidence-based frame.
间质性肺疾病（ILD）是慢性肺部疾病中导致死亡的主要原因。ILD源于大量病理生理因素。其中一个原因是结缔组织病（CTD）。据专家称，CTD-ILD患者的疾病活动可能稳定，无需常规治疗。此外，通过肺康复（PR），这些患者可能会从改善临床结局和降低死亡率中获益。然而，这些患者的特征以及他们在实际中疾病活动是否稳定尚不清楚。
通过人工智能驱动的工具对六个数据库进行系统评价以开展文献研究。评估了研究的方法学质量、偏倚风险和证据水平。
根据最终纳入的四项研究，肺康复对肺功能、弥散能力、功能能力、生活质量、呼吸困难严重程度和疲劳水平有中等证据水平的益处。然而，关于CTD-ILD患者的呼吸功能和外周肌肉力量的证据有限。
文献表明，肺康复在CTD-ILD中的应用并不广泛。我们的研究结果表明，肺康复可用于CTD-ILD以恢复临床参数，如肺功能、生活质量、呼吸困难严重程度和疲劳水平。应开展更全面的研究以揭示肺康复在循证框架中的作用。
