Zhang LiGong, Zhu Chao, Guo Chenxu, Yin FaXiang, Xie Qiang, Tao Min
Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Surgical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
J Biochem Mol Toxicol. 2024 Dec;38(12):e70081. doi: 10.1002/jbt.70081.
Breast cancer (BRCA) is one of the major threats to women's health worldwide. This study focuses on the roles of sorbin and SH3 domain-containing protein 2 (SORBS2) protein and microRNA-138-5p in the progression of BRCA, analyzing their regulatory effects on cancer cell proliferation, cell cycle, and migration ability. Using bioinformatics tools and experimental methods, the study found that SORBS2 is commonly underexpressed in BRCA. Additionally, it demonstrated that microRNA-138-5p can significantly inhibit tumor growth by suppressing SORBS2 expression, providing new molecular targets for BRCA treatment.
乳腺癌（BRCA）是全球女性健康的主要威胁之一。本研究聚焦于含sorbin和SH3结构域蛋白2（SORBS2）以及微小RNA - 138 - 5p在BRCA进展中的作用，分析它们对癌细胞增殖、细胞周期及迁移能力的调控作用。通过生物信息学工具和实验方法，该研究发现SORBS2在BRCA中通常表达不足。此外，研究表明微小RNA - 138 - 5p可通过抑制SORBS2表达显著抑制肿瘤生长，为BRCA治疗提供了新的分子靶点。
