Shenoy Dhriti, Chivukula Sowmya, Erdogan Nursu, Chiesa Enrica, Pellegrino Sara, Reches Meital, Genta Ida
DISFARM, Dipartimento Di Scienze Farmaceutiche, Sezione Chimica Generale e Organica "A. Marchesini", Università degli Studi di Milano, Milan, Italy.
Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
J Mater Chem B. 2025 Jan 15;13(3):844-857. doi: 10.1039/d4tb01235f.
Cardiovascular diseases are the leading cause of death worldwide, claiming millions of lives every year. Cardiac tissue engineering has emerged as a versatile option for repairing cardiac tissue and helping its regeneration. The use of nanomaterials, particularly nanofiber-based scaffolds combined with biomolecular cues like peptides, has significantly improved the compatibility and efficacy of the scaffolds for cardiac tissue regeneration. By utilising the self-assembly properties of peptides to create nanofiber scaffolds, we can achieve stability that closely mimics the natural components of cardiac tissue, making them perfect for cardiac tissue regeneration. In this review, we highlighted the dynamic process of self-assembly into nanofibers and the use of various self-assembled nanofibers for cardiovascular tissue regeneration, focusing on their roles in antithrombotic, angiogenic, differentiation, proliferation, and anti-atherosclerotic interventions.
心血管疾病是全球主要的死亡原因，每年夺去数百万人的生命。心脏组织工程已成为修复心脏组织并促进其再生的一种通用选择。纳米材料的使用，特别是基于纳米纤维的支架与肽等生物分子线索相结合，显著提高了支架在心脏组织再生方面的兼容性和功效。通过利用肽的自组装特性来创建纳米纤维支架，我们可以实现与心脏组织天然成分非常相似的稳定性，使其非常适合心脏组织再生。在本综述中，我们重点介绍了自组装成纳米纤维的动态过程以及各种自组装纳米纤维在心血管组织再生中的应用，重点关注它们在抗血栓形成、血管生成、分化、增殖和抗动脉粥样硬化干预中的作用。
