Pang Qian, Huo Fangjun, Yin Caixia
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, China.
Research Institute of Applied Chemistry, Shanxi University, Taiyuan, 030006, China.
Chembiochem. 2025 Feb 3;26(5):e202400817. doi: 10.1002/cbic.202400817. Epub 2024 Dec 10.
Hydrogen sulfide (HS) serves as the third gasotransmitter, crucial in various physiological processes involving its production and metabolism. Elevated levels of HS can result in acute or chronic poisoning, whereas lower concentrations are involved in regulating diverse physiological and pathological activities within the human body. Moreover, it actively participates in maintaining normal cellular function by exerting cell protection and anti-apoptotic effects. In recent years, extensive research has been conducted to explore the physiological significance of HS and its potential applications in developing prodrugs. To further unravel the biological and clinical potential of HS, HS donors have gained widespread utilization. These compounds facilitate our understanding of the specific functional aspects governed by HS and hold promise as potential therapeutic agents. Therefore, it is necessary to study HS as a delivery vehicle at the cellular and in vivo levels. This review provides an overview of advancements made over the past five years regarding HS donors and their applications in biology, encompassing indirectly released donors of carbonyl sulfide (COS), directly released small molecule donors, Nanocomposite scaffolds, and hydrogels.
硫化氢（HS）作为第三种气体信号分子，在其产生和代谢的各种生理过程中起着至关重要的作用。HS水平升高会导致急性或慢性中毒，而较低浓度则参与调节人体内各种生理和病理活动。此外，它通过发挥细胞保护和抗凋亡作用，积极参与维持正常细胞功能。近年来，人们进行了广泛的研究，以探索HS的生理意义及其在开发前药方面的潜在应用。为了进一步揭示HS的生物学和临床潜力，HS供体已得到广泛应用。这些化合物有助于我们了解HS所支配的特定功能方面，并有望成为潜在的治疗药物。因此，有必要在细胞和体内水平上研究HS作为一种递送载体。本综述概述了过去五年中关于HS供体及其在生物学中的应用的进展，包括间接释放的羰基硫（COS）供体、直接释放的小分子供体、纳米复合支架和水凝胶。
