Bräutigam Matilda, Dellenmark-Blom Michaela, Abrahamsson Kate, Gatzinsky Cathrine, Gatzinsky Vladimir
Department of Pediatric Surgery, Queen Silvia Children's Hospital, Sahlgrenska University, Hospital, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, 416 85, Gothenburg, Sweden.
Pediatr Surg Int. 2024 Dec 10;41(1):24. doi: 10.1007/s00383-024-05909-4.
The aim was to determine gastrointestinal (GI)-related QoL in children born with gastroschisis (GS).
Totally, 58/83 families of children (aged 2-18 years) operated for GS at a tertiary pediatric surgical center accepted participation. Children aged 5-18 and one parent (child aged 2-18) completed the Swedish version of the PedsQL™ gastrointestinal symptoms module, evaluating GI-related QoL with 14 different GI-specific scales, norm values for Hirschsprung's disease (HD), esophageal atresia (EA), and functional constipation (FC) that were used for comparison.
Children with GS had significantly lower parent-reported scores on "Gas and bloating" compared with children with EA (77.0 vs 85.5, p = 0.039). In the child report and in the parent report, scores on several GI scales were like those of children with EA. Parents of children with GS had higher scores for 8/14 scales compared to HD and higher scores for 12/14 scales compared to FC. Clinical GS-specific factors for worse GI-QoL were identified, including "Days in ventilator" and "Days with Silo and Patch".
GS has an impact on GI-related QoL, comparable to that in EA, but not to HD or FC. The GS-specific factors of worse QoL show the importance regarding a GS follow-up program including considering clinical factors.
本研究旨在确定患有腹裂（GS）的儿童的胃肠道（GI）相关生活质量。
在一家三级儿科手术中心，共有83例接受GS手术的儿童（年龄在2至18岁之间）中的58个家庭同意参与研究。年龄在5至18岁的儿童以及一名家长（孩子年龄在2至18岁）完成了瑞典语版的儿童生活质量量表（PedsQL™）胃肠道症状模块，该模块使用14种不同的胃肠道特异性量表评估GI相关生活质量，并将先天性巨结肠（HD）、食管闭锁（EA）和功能性便秘（FC）的常模值用于比较。
与EA患儿相比，GS患儿的家长报告的“气体和腹胀”得分显著更低（77.0对85.5，p = 0.039）。在儿童报告和家长报告中，几个胃肠道量表的得分与EA患儿相似。与HD相比，GS患儿的家长在14个量表中的8个得分更高，与FC相比，在14个量表中的12个得分更高。确定了与较差的胃肠道生活质量相关的临床GS特异性因素，包括“呼吸机使用天数”和“使用肠袋和补片的天数”。
GS对GI相关生活质量有影响，与EA相当，但与HD或FC不同。较差生活质量的GS特异性因素表明了GS随访计划的重要性，包括考虑临床因素。
