Huang Shaowen, Qiu Xiaoqi
Emergency Department, Shenzhen Baoan Wonmen's and Children's Hospital, Shenzhen, 518100, China.
Mol Biotechnol. 2024 Dec 10. doi: 10.1007/s12033-024-01339-8.
The study aims to analyze the correlation between Regulatory T(Treg) Cells and inflammatory stress response and immune response in sepsis patients. Sixty sepsis patients admitted between January 2021 and June 2023 were selected as the subjects and included in the observation group. During the same period, 80 healthy children who underwent physical examinations in the hospital were included in the control group. The Treg content, inflammatory mediators, and immune response biochemical indicators of two groups are compared. The Pearson correlation analysis verifies the correlation between Treg content and inflammatory stress response, and immune response. Treg content in the observation group exceeded that found in the control group (P < 0.05). Among the relevant biochemical indicators, Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Procalcitonin (PCT), and Hypersensitive C-reactive protein (hs-CRP) exceeded that found in healthy children (P < 0.05). The immunoglobulin IgA, IgM, and IgG in healthy children were below respective values in the control group (P < 0.05). The Pearson correlation data demonstrated that the peripheral blood Treg content in children with sepsis was positively related to inflammatory mediator indicators. It was negatively related with the immunoglobulin IgA, IgM, and IgG. In summary, when the Treg content in the peripheral blood of sepsis patients increases, it directly affects the body's inflammatory stress response and immune function.
本研究旨在分析脓毒症患者中调节性T（Treg）细胞与炎症应激反应及免疫反应之间的相关性。选取2021年1月至2023年6月期间收治的60例脓毒症患者作为研究对象，纳入观察组。同期选取80例在本院进行体检的健康儿童作为对照组。比较两组的Treg含量、炎症介质及免疫反应生化指标。采用Pearson相关性分析验证Treg含量与炎症应激反应及免疫反应之间的相关性。观察组Treg含量高于对照组（P＜0.05）。在相关生化指标中，肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、降钙素原（PCT）及超敏C反应蛋白（hs-CRP）均高于健康儿童（P＜0.05）。健康儿童的免疫球蛋白IgA、IgM及IgG均低于对照组相应值（P＜0.05）。Pearson相关性分析数据显示，脓毒症患儿外周血Treg含量与炎症介质指标呈正相关，与免疫球蛋白IgA、IgM及IgG呈负相关。综上所述，脓毒症患者外周血Treg含量升高时，直接影响机体的炎症应激反应及免疫功能。
