Fu Jiaqi, An Li
Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang North New Area, Shenyang, Liaoning, China.
Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, China.
Aging Dis. 2024 Nov 15;16(5):2831-2858. doi: 10.14336/AD.2024.0899.
Alzheimer's disease (AD) is an insidious, progressive, and irreversible neurodegenerative disease characterized by the deposition of extracellular amyloid β-protein (Aβ) to form senile plaques and abnormal phosphorylation of intracellular tau protein to form neuronal fiber tangles. The pathogenesis of AD is complex, and there are several hypotheses, primarily including the Aβ cascade hypothesis, the neurofibrillary tangle hypothesis, the inflammatory hypothesis, and the cholinergic hypothesis. It has been suggested that the dysregulation of multiple energy metabolic pathways, especially mitochondria metabolism, may be related to the severity of AD pathology and disease symptoms in the brain. The modification of histone (lysine) methylation, an actively regulated and reversible process, is closely related to energy metabolism and plays a crucial role in AD development. In summary, histone methylation, energy metabolism, and AD restricted and regulated each other. Here, we review the advances in the correlation between histone methylation, energy metabolism, and AD. This can provide further insights into the mechanisms underlying AD pathogenesis and its control.
阿尔茨海默病（AD）是一种隐匿性、进行性且不可逆的神经退行性疾病，其特征在于细胞外淀粉样β蛋白（Aβ）沉积形成老年斑，以及细胞内tau蛋白异常磷酸化形成神经纤维缠结。AD的发病机制复杂，有多种假说，主要包括Aβ级联假说、神经纤维缠结假说、炎症假说和胆碱能假说。有人提出，多种能量代谢途径的失调，尤其是线粒体代谢，可能与AD病理的严重程度及大脑中的疾病症状有关。组蛋白（赖氨酸）甲基化修饰是一个受主动调控且可逆的过程，与能量代谢密切相关，并在AD发展中起关键作用。总之，组蛋白甲基化、能量代谢和AD相互制约、相互调控。在此，我们综述组蛋白甲基化、能量代谢与AD之间相关性的研究进展。这可为深入了解AD发病机制及其调控机制提供进一步的见解。
