Sutton Brian
Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.
Sci Signal. 2024 Dec 10;17(866):eadu0382. doi: 10.1126/scisignal.adu0382.
Immunoglobulin E (IgE) binds with high affinity to its receptor, FcεRI, on mast cells and basophils, and cross-linking of allergen-specific IgE by minute amounts of multivalent allergen stimulates a powerful and immediate allergic reaction. In this issue of , Zhang report the three-dimensional structures of the human and murine receptors, with and without bound IgE-Fc, to reveal some intriguing differences between mouse and human in this critical antibody-receptor interaction.
免疫球蛋白E（IgE）以高亲和力与其在肥大细胞和嗜碱性粒细胞上的受体FcεRI结合，微量多价变应原使变应原特异性IgE发生交联，可刺激强烈且迅速的过敏反应。在本期杂志中，张等人报道了结合和未结合IgE-Fc的人源和鼠源受体的三维结构，揭示了在这种关键的抗体-受体相互作用中，小鼠和人类之间存在一些有趣的差异。
