Nowlan Kirsten, Hannolainen Leo, Assimakopoulou Irini M, Dürnsteiner Pia, Sarkkinen Joona, Suokas Santeri, Hedman Lea, Tienari Pentti J, Hedman Klaus, Niku Mikael, Aaltonen Leena-Maija, Huuskonen Antti, Räsänen Jari V, Ilonen Ilkka K, Mäyränpää Mikko I, Dunkel Johannes, Laakso Sini M, Söderlund-Venermo Maria, Perdomo Maria F, Kekäläinen Eliisa
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
J Infect Dis. 2025 Apr 15;231(4):e601-e606. doi: 10.1093/infdis/jiae600.
Myasthenia gravis (MG) is a rare autoimmune disorder characterized by muscle weakness resulting from autoantibody-mediated disruption of the neuromuscular junction. Notably, it is also frequently associated with thymic pathology. This study explores the relationship between MG and DNA viruses in the thymus, employing targeted next-generation sequencing and quantitative polymerase chain reaction to analyze thymic tissue samples from both patients with MG and healthy controls. We detected human herpes virus 6B and 7, Epstein-Barr virus, and parvovirus B19 (B19V) across various tissue groups. However, no significant enrichment of these viruses was observed in the thymic tissue of patients with MG.
重症肌无力（MG）是一种罕见的自身免疫性疾病，其特征是自身抗体介导的神经肌肉接头破坏导致肌肉无力。值得注意的是，它也常与胸腺病变相关。本研究利用靶向二代测序和定量聚合酶链反应分析MG患者和健康对照的胸腺组织样本，探讨胸腺中MG与DNA病毒之间的关系。我们在不同组织组中检测到了人类疱疹病毒6B和7、爱泼斯坦-巴尔病毒以及细小病毒B19（B19V）。然而，在MG患者的胸腺组织中未观察到这些病毒的显著富集。
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