Baker J K, Little T L
J Med Chem. 1985 Jan;28(1):46-50. doi: 10.1021/jm00379a011.
The transformation of phencyclidine in a mouse liver microsome preparation to several oxidative metabolites was studied. With use of GLC and HPLC methods with internal standards, phencyclidine and six metabolites were quantitated and the amino acid 12, resulting from the alpha-oxidation of the piperidine ring, was produced in 10-50 times greater amounts than the other metabolites. While most piperidines and pyrrolidines produce an amino acid and a corresponding lactam, it was found that phencyclidine was not converted to the lactam 11.
研究了苯环利定在小鼠肝脏微粒体制剂中转化为几种氧化代谢物的过程。使用带有内标的气相色谱法（GLC）和高效液相色谱法（HPLC）对苯环利定和六种代谢物进行了定量分析，哌啶环α-氧化产生的氨基酸12的生成量比其他代谢物多10至50倍。虽然大多数哌啶和吡咯烷会产生一种氨基酸和一种相应的内酰胺，但发现苯环利定不会转化为内酰胺11。
