Yu Kang, Luo Huihuan, Zhao Jie, Wu Yiqun, Yu Dedong
Department of Second Dental Center, Ninth People's Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
Arch Oral Biol. 2025 Mar;171:106150. doi: 10.1016/j.archoralbio.2024.106150. Epub 2024 Dec 7.
This study aims to evaluate the genetic association between emotional disorders and TMD-related pain through two-sample Mendelian randomization analysis.
Single-nucleotide polymorphisms (SNPs) related to emotional disorders (worry, nerves, or depression) were selected from genome-wide association studies (GWAS) from UK Biobank consortia, and related these to SNPs from FinnGen consortia. The inverse-variance weighted (IVW) was used as the primary effect estimate between emotional disorders and TMD-related pain, and various methods were applied to test the reliability and stability of the results, namely MR-Egger and weighted median.
The Mendelian randomization analysis showed that there was a positive correlation between emotional disorders and TMD-related pain, including worry group (IVW odds ratio (OR) = 3.86, 95 % confidence interval (CI) = 1.67-8.91), nerves group (IVW OR = 11.20, 95 % CI=2.04-61.64) and depression group (IVW OR = 3.32, 95 % CI=1.24-8.90). MR-Egger intercept and MR-PRESSO global test did not suggest evidence of horizontal or directional pleiotropy. Cochran's Q test showed that there was no heterogeneity between instrumental variables.
This study provides genetic evidence that strengthens the connection between emotional disorders and TMD-related pain, which has important implications at the causal level as well as throughout the treatment process of TMD-related pain.
本研究旨在通过两样本孟德尔随机化分析评估情绪障碍与颞下颌关节紊乱症（TMD）相关疼痛之间的遗传关联。
从英国生物银行联盟的全基因组关联研究（GWAS）中选择与情绪障碍（担忧、紧张或抑郁）相关的单核苷酸多态性（SNP），并将其与芬兰基因联盟的SNP相关联。采用逆方差加权（IVW）作为情绪障碍与TMD相关疼痛之间的主要效应估计，并应用多种方法检验结果的可靠性和稳定性，即MR-Egger和加权中位数法。
孟德尔随机化分析表明，情绪障碍与TMD相关疼痛之间存在正相关，包括担忧组（IVW比值比（OR）=3.86，95%置信区间（CI）=1.67-8.91）、紧张组（IVW OR=11.20，95%CI=2.04-61.64）和抑郁组（IVW OR=3.32，95%CI=1.24-8.90）。MR-Egger截距和MR-PRESSO全局检验未提示存在水平或定向多效性的证据。 Cochr an Q检验表明工具变量之间不存在异质性。
本研究提供了遗传证据，强化了情绪障碍与TMD相关疼痛之间的联系，这在因果层面以及TMD相关疼痛的整个治疗过程中都具有重要意义。
