Yang Peiwen, Shang Yueyong, Qu Bin, Zhang Jinping, Khalil Muhammad Faisal, Hu Menghong, Wang Youji
International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China.
International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China; Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai 201306, China.
Mar Pollut Bull. 2025 Feb;211:117437. doi: 10.1016/j.marpolbul.2024.117437. Epub 2024 Dec 9.
In the marine environment, various weathering effects on micro or nanoplastics lead to surface modifications, which in turn alter their toxic effects on aquatic organisms. This study investigated the impact of three types of nanoplastics (NPs, NPs-NH, NPs-COOH) on the antioxidant capacity of Mytilus coruscus gills, mantle, and hemolymph over 28 days. Analyzed key antioxidant stress indicators (CAT, SOD, GSH, GSH-Px, MDA, HO) and conducted IBR and PCA analyses to evaluate the toxic effects of modified nanoplastics. In particular, NPs-NH showed the most significant inhibition of antioxidant enzymes like CAT and GSH-Px in gills and mantle, while NPs-COOH affected a wider range of oxidative stress markers. Furthermore, tissue-specific responses were observed, with gills being the most sensitive to biomarker changes. Overall, NPs-NH emerged as the most toxic nanoplastic, highlighting the need to assess ecological risks associated with novel nanoparticles in marine environments and offering insights into tissue-specific toxicity in mussels.
在海洋环境中，微塑料或纳米塑料受到的各种风化作用会导致其表面改性，进而改变它们对水生生物的毒性作用。本研究调查了三种类型的纳米塑料（NPs、NPs-NH、NPs-COOH）在28天内对波纹巴非蛤鳃、外套膜和血淋巴抗氧化能力的影响。分析了关键抗氧化应激指标（CAT、SOD、GSH、GSH-Px、MDA、HO），并进行综合生物标志物响应（IBR）和主成分分析（PCA）以评估改性纳米塑料的毒性作用。特别是，NPs-NH对鳃和外套膜中的CAT和GSH-Px等抗氧化酶表现出最显著的抑制作用，而NPs-COOH影响了更广泛的氧化应激标志物。此外，还观察到了组织特异性反应，鳃对生物标志物变化最为敏感。总体而言，NPs-NH是毒性最强的纳米塑料，这凸显了评估海洋环境中新型纳米颗粒相关生态风险的必要性，并为贻贝的组织特异性毒性提供了见解。
