Lestariningsih Sri, Tamtomo Didik Gunawan, Sulistyowati Sri, Indarto Dono, Soetrisno Soetrisno, Hidayati Hanik Badriyah, Widada Wahyudi
Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, 57126, Indonesia; Midwifery Program, Tanjungkarang Ministry of Health Polytechnic, Metro City, Sumatera, Lampung, Indonesia.
Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, 57126, Indonesia.
J Ayurveda Integr Med. 2024 Nov-Dec;15(6):101047. doi: 10.1016/j.jaim.2024.101047. Epub 2024 Dec 9.
Primary dysmenorrhea (PD) is characterized by discomfort with no organic etiology (no pelvic disease), recurring pain, or lower abdominal cramps that start between the first 8-72 h of menstruation. Cupping therapy uses a tool to form a vacuum at certain points on the skin.
We investigated the mechanism of pain relief caused by cupping therapy in primary dysmenorrhea that is played by cupping therapy in PD. This study aimed to investigate the effects of the cupping method on pain symptoms, changes in PGF2α, PGE, and β-endorphin levels, and uterine morphology in PD.
A total of 35 female rats were divided into five groups (n = 7 rats per group): control, PD, dysmenorrhea treated with dry cupping (DC), dysmenorrhea treated with wet cupping (WC), and dysmenorrhea treated with ibuprofen (IB) as a standard drug. Pain was assessed by measuring the degree of writhing pain. Serum PGF2α, PGE, and β-endorphin levels were evaluated using ELISA. Hematoxylin-eosin staining was used to examine uterine morphology, such as thickness, vacuolization, and inflammation.
WC had a pain normalization effect comparable to that of ibuprofen. Ibuprofen is superior to both types of cupping in reducing the PGF2α/PGE ratio and the PGF2α to β-endorphins ratio. WC and DC have capabilities comparable to those of ibuprofen in improving uterine vacuolization and inflammation.
These results indicate that WC is more effective than DC in suppressing dysmenorrhea symptoms, modulating the hormone level ratio, and repairing uterine pathology. The potential benefits of cupping provide an opportunity for further studies in human subjects.
原发性痛经（PD）的特征是无器质性病因（无盆腔疾病）引起的不适、反复疼痛或在月经开始后的最初8 - 72小时内出现的下腹绞痛。拔罐疗法使用一种工具在皮肤上的特定部位形成真空。
我们研究了拔罐疗法在原发性痛经中缓解疼痛的机制。本研究旨在探讨拔罐方法对原发性痛经患者疼痛症状、前列腺素F2α（PGF2α）、前列腺素E（PGE）和β-内啡肽水平变化以及子宫形态的影响。
总共35只雌性大鼠被分为五组（每组n = 7只大鼠）：对照组、原发性痛经组、干罐法治疗痛经组（DC）、湿罐法治疗痛经组（WC）以及以布洛芬（IB）作为标准药物治疗痛经组。通过测量扭体疼痛程度来评估疼痛。使用酶联免疫吸附测定法（ELISA）评估血清PGF2α、PGE和β-内啡肽水平。苏木精-伊红染色用于检查子宫形态，如厚度、空泡化和炎症。
湿罐法具有与布洛芬相当的疼痛缓解效果。在降低PGF2α/PGE比值和PGF2α与β-内啡肽的比值方面，布洛芬优于两种拔罐方法。在改善子宫空泡化和炎症方面，湿罐法和干罐法具有与布洛芬相当的能力。
这些结果表明，在抑制痛经症状、调节激素水平比值和修复子宫病理方面，湿罐法比干罐法更有效。拔罐的潜在益处为在人类受试者中进行进一步研究提供了机会。
