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温和灸对原发性痛经大鼠模型子宫血管及前列腺素含量的调节作用

Regulation of Mild Moxibustion on Uterine Vascular and Prostaglandin Contents in Primary Dysmenorrhea Rat Model.

作者信息

Li Xuemei, Guo Sha, Chen Zhaoheng, Ren Kuiyu, Zhang Hong, Yu Shuguang, Yang Sha

机构信息

Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.

出版信息

Evid Based Complement Alternat Med. 2021 Jul 10;2021:9949642. doi: 10.1155/2021/9949642. eCollection 2021.

DOI:10.1155/2021/9949642
PMID:34335847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8286201/
Abstract

OBJECTIVE

Primary dysmenorrhea (PD) is a common and high incidence disease in gynecology, which seriously affects the quality of life in young women. Our previous study found that mild moxibustion could treat abdominal pain of PD patients, but the mechanism is still unclear. Therefore, this study aims to partly investigate the treatment mechanism of moxibustion for PD, especially on uterine microcirculation.

METHODS

Forty 3-month-old Sprague Dawley female rats were randomly divided into four groups, including group A (saline control group,  = 10), group B (control plus moxibustion group,  = 10), group C (PD model group,  = 10), group D (PD. model plus moxibustion group,  = 10). The PD rat model was established by injecting estradiol benzoate and oxytocin. Mild moxibustion on Sanyinjiao (SP6) and Guanyuan (CV4) acupoints was once a day, 20 minutes per time, for 10 consecutive days. A vaginal smear was used to test the estrous cycle of rats. Uterine microvascular thickness was observed by stereomicroscope. And we detected the content of prostaglandin F (PGF ) and prostaglandin E (PGE) in uterine tissue by enzyme-linked immunosorbent assay.

RESULTS

Mild moxibustion can enlarge the microvessels, improve the microcirculation disturbance, and relieve the swelling of the uterus in PD rats. During the mild moxibustion intervention, the contents of PGF and PGE in uterus issues were synchronous increases or decreases and the changes of PGE were more obvious, but the changes of uterine microvasculature and morphology caused by the decrease of PGF were greater than PGE.

CONCLUSION

Mild moxibustion at SP6 and CV4 acupoints may relax uterine microvascular obstacle by reducing the content of PGF in uterine tissue, improve the microcirculation disorder, and then alleviate the PD rat's uterine swelling.

摘要

目的

原发性痛经（PD）是妇科常见的高发病，严重影响年轻女性的生活质量。我们之前的研究发现温和灸可治疗PD患者的腹痛，但机制尚不清楚。因此，本研究旨在部分探讨艾灸治疗PD的机制，尤其是对子宫微循环的影响。

方法

将40只3月龄的Sprague Dawley雌性大鼠随机分为四组，包括A组（生理盐水对照组，n = 10）、B组（对照加艾灸组，n = 10）、C组（PD模型组，n = 10）、D组（PD模型加艾灸组，n = 10）。通过注射苯甲酸雌二醇和缩宫素建立PD大鼠模型。对三阴交（SP6）和关元（CV4）穴位进行温和灸，每天1次，每次20分钟，连续10天。采用阴道涂片检测大鼠的发情周期。通过体视显微镜观察子宫微血管厚度。并采用酶联免疫吸附测定法检测子宫组织中前列腺素F（PGF）和前列腺素E（PGE）的含量。

结果

温和灸可扩张微血管，改善PD大鼠的微循环障碍，减轻子宫肿胀。在温和灸干预期间，子宫组织中PGF和PGE的含量同步增减，且PGE的变化更明显，但PGF降低引起的子宫微血管形态变化大于PGE。

结论

对SP6和CV4穴位进行温和灸可能通过降低子宫组织中PGF的含量缓解子宫微血管障碍，改善微循环障碍，进而减轻PD大鼠的子宫肿胀。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/83aa73bb25d9/ECAM2021-9949642.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/5763b5072588/ECAM2021-9949642.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/e3bfb98f8102/ECAM2021-9949642.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/0504ecaa8341/ECAM2021-9949642.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/453aa51931ff/ECAM2021-9949642.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/98ea4c97d1c2/ECAM2021-9949642.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/83aa73bb25d9/ECAM2021-9949642.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/5763b5072588/ECAM2021-9949642.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/e3bfb98f8102/ECAM2021-9949642.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/0504ecaa8341/ECAM2021-9949642.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/453aa51931ff/ECAM2021-9949642.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/98ea4c97d1c2/ECAM2021-9949642.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4f/8286201/83aa73bb25d9/ECAM2021-9949642.006.jpg

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