Liu Shuxun, Feng Xujie, Zhang Hangjia, Li Ping, Yang Baoru, Gu Qing
Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310018, China.
Food Chemistry and Food Development, Department of Biochemistry, University of Turku, Turku FI-20014, Finland.
Microbiol Res. 2025 Mar;292:127995. doi: 10.1016/j.micres.2024.127995. Epub 2024 Dec 6.
This review provides a comprehensive analysis of the intricate architecture of bacterial sensing systems, with a focus on signal transduction mechanisms and their critical roles in microbial physiology. It highlights quorum sensing (QS), quorum quenching (QQ), and quorum sensing interference (QSI) as fundamental processes driving bacterial communication, influencing gene expression, biofilm formation, and interspecies interactions. The analysis explores the importance of diffusible signal factors (DSFs) and secondary messengers such as cAMP and c-di-GMP in modulating microbial behaviors. Additionally, cross-kingdom signaling, where bacterial signals impact host-pathogen dynamics and ecological balance, is systematically reviewed. This review introduces "signalomics", an novel interdisciplinary framework integrating genomics, proteomics, and metabolomics to offer a holistic framework for understanding microbial communication and evolution. These findings hold significant implications for various domains, including food preservation, agriculture, and human health.
本综述对细菌传感系统的复杂结构进行了全面分析，重点关注信号转导机制及其在微生物生理学中的关键作用。它强调群体感应（QS）、群体猝灭（QQ）和群体感应干扰（QSI）是驱动细菌通讯、影响基因表达、生物膜形成和种间相互作用的基本过程。分析探讨了可扩散信号因子（DSF）以及诸如cAMP和c-di-GMP等第二信使在调节微生物行为中的重要性。此外，还系统综述了细菌信号影响宿主-病原体动态和生态平衡的跨界信号传导。本综述引入了“信号组学”，这是一个整合基因组学、蛋白质组学和代谢组学的新型跨学科框架，为理解微生物通讯和进化提供了一个整体框架。这些发现对包括食品保鲜、农业和人类健康在内的各个领域都具有重要意义。
