Chigozie Victor U, Saki Morteza, Esimone Charles O
Department of Pharmaceutical Microbiology and Biotechnology, David Umahi Federal University of Health Sciences, Ohaozara, Ebonyi State, Nigeria.
International Institute for Pharmaceutical Research (IIPR), Ohaozara, Ebonyi State, Nigeria.
World J Microbiol Biotechnol. 2025 Feb 13;41(2):71. doi: 10.1007/s11274-025-04280-3.
Quorum sensing (QS) regulates bacterial behaviors such as biofilm formation, virulence, and metabolite production through signaling molecules like acyl-homoserine lactones (AHLs), peptides, and AI-2. These signals are pivotal in bacterial communication, influencing pathogenicity and industrial applications. This review explores the molecular architecture of QS signals and their role in metabolite production, emphasizing structural modifications that disrupt bacterial communication to control virulence and enhance industrial processes. Key findings highlight the development of synthetic QS analogs, engineered inhibitors, and microbial consortia as innovative tools in biotechnology and medicine. The review underscores the potential of molecular engineering in managing microbial behaviors and optimizing applications like biofuel production, bioplastics, and anti-virulence therapies. Additionally, cross-species signaling mechanisms, particularly involving AI-2, reveal new opportunities for regulating interspecies cooperation and competition. This synthesis aims to bridge molecular insights with practical applications, showcasing how QS-based technologies can drive advancements in microbial biotechnology and therapeutic strategies.
群体感应（QS）通过酰基高丝氨酸内酯（AHLs）、肽和AI-2等信号分子调节细菌行为，如生物膜形成、毒力和代谢产物产生。这些信号在细菌通讯中至关重要，影响致病性和工业应用。本综述探讨了群体感应信号的分子结构及其在代谢产物产生中的作用，强调了破坏细菌通讯以控制毒力和增强工业过程的结构修饰。主要发现突出了合成群体感应类似物、工程抑制剂和微生物群落作为生物技术和医学创新工具的发展。该综述强调了分子工程在管理微生物行为和优化生物燃料生产、生物塑料和抗毒力疗法等应用方面的潜力。此外，跨物种信号传导机制，特别是涉及AI-2的机制，揭示了调节种间合作与竞争的新机会。本综述旨在将分子见解与实际应用联系起来，展示基于群体感应的技术如何推动微生物生物技术和治疗策略的进步。
