McCready R A, Price M A, Kryscio R J, Hyde G L, Mattingly S S, Griffen W O
J Vasc Surg. 1985 Jan;2(1):205-13.
To evaluate the effect of ibuprofen (Motrin) on the development of neointimal fibrous hyperplasia (NFH), 4 cm segments of expanded polytetrafluoroethylene (ePTFE) grafts with an internal diameter of 4 mm were implanted in the femoral arteries of 28 dogs. Three dogs served as controls and these grafts were removed at 7 to 14 days. The remaining 25 dogs were medicated with either intravenous (IV) or oral (PO) ibuprofen. The medicated dogs were grouped according to whether the ibuprofen was administered prior to or after graft implantation. The orally medicated dogs were also grouped according to whether the grafts were removed from 30 to 60 days after graft implantation. The grafts were analyzed for the amount of anastomotic initimal hyperplasia, pannus extension, thrombus deposition, and patency. Analysis of the data demonstrated no statistically significant differences among any of the treatment groups or the control group for the variables analyzed. We conclude that ibuprofen neither prevents nor retards the development of NFH. There was a trend toward less thrombus deposition in the animals that received oral ibuprofen preoperatively. There was also a trend toward higher patency in the animals that received ibuprofen prior to graft implantation, which most likely resulted from decreased thrombus and fibrin deposition.
为评估布洛芬（Motrin）对新生内膜纤维增生（NFH）发展的影响，将内径4mm、长4cm的膨体聚四氟乙烯（ePTFE）移植物植入28只犬的股动脉。3只犬作为对照，这些移植物在7至14天取出。其余25只犬接受静脉注射（IV）或口服（PO）布洛芬治疗。用药犬根据布洛芬在移植物植入前或后给药进行分组。口服给药的犬也根据移植物在植入后30至60天取出与否进行分组。对移植物进行吻合口内膜增生、血管翳延伸、血栓沉积和通畅情况的分析。数据分析表明，在所分析的变量方面，任何治疗组与对照组之间均无统计学显著差异。我们得出结论，布洛芬既不能预防也不能延缓NFH的发展。术前接受口服布洛芬的动物血栓沉积有减少趋势。在移植物植入前接受布洛芬的动物通畅率也有升高趋势，这很可能是由于血栓和纤维蛋白沉积减少所致。
