2023 - 2024年人类免疫因子对甲型流感病毒（H5N1）2.3.4.4b分支病毒的复制限制
Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023-2024.
作者信息
Ankerhold Jakob, Kessler Susanne, Beer Martin, Schwemmle Martin, Ciminski Kevin
出版信息
Emerg Infect Dis. 2025 Jan;31(1):199-202. doi: 10.3201/eid3101.241236. Epub 2024 Dec 10.
Abstract
We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components from a human-adapted MxA-resistant strain in vitro.
摘要
我们发现，人类黏液病毒抗性蛋白1（MxA）在体外和MxA转基因小鼠中可抑制从哺乳动物分离出的高致病性甲型禽流感病毒（H5N1）的复制。然而，H5N1可通过在体外从人源适应性MxA抗性毒株替换单个病毒聚合酶复合物成分来逃避MxA的限制。
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