Ouriel K, Smedira N G, Ricotta J J
J Vasc Surg. 1985 Jan;2(1):49-53.
Free radicals have been implicated in the damage caused by tissue ischemia and reperfusion. Canine kidneys were subjected to a 60-minute period of normothermic ischemia. One group of animals received intra-arterial superoxide dismutase (SOD, 17.6 mg/50 ml, 50,000 units) at the end of the ischemic period, whereas a second group received albumin (17.6 mg/50 ml). The kidneys treated with SOD demonstrated significantly less edema formation (1.0 +/- 0.3% wet weight vs. 1.8 +/- 0.2%, mean +/- SEM, p less than 0.05) and lower renovascular resistance (44.0 +/- 5.6 dynes-sec/cm5 vs. 64.0 +/- 12.0, p less than 0.05). The SOD group displayed greater preservation of both glomerular filtration rate (45.9 +/- 6.1% of baseline vs. 23.7 +/- 5.8%, p less than 0.05) and urine flow (1.3 +/- 0.4 ml/min vs. 0.3 +/- 0.1, p less than 0.05). We conclude that the free radical scavenger SOD provides significant protection of the kidney during ischemia and reperfusion.
自由基与组织缺血和再灌注所造成的损伤有关。犬肾经历了60分钟的常温缺血。一组动物在缺血期结束时接受动脉内超氧化物歧化酶（SOD，17.6毫克/50毫升，50,000单位），而另一组接受白蛋白（17.6毫克/50毫升）。用SOD处理的肾脏显示出明显较少的水肿形成（湿重1.0 +/- 0.3% 对比1.8 +/- 0.2%，平均值 +/- 标准误，p小于0.05）和较低的肾血管阻力（44.0 +/- 5.6达因-秒/厘米⁵ 对比64.0 +/- 12.0，p小于0.05）。SOD组在肾小球滤过率（为基线的45.9 +/- 6.1% 对比23.7 +/- 5.8%，p小于0.05）和尿流（1.3 +/- 0.4毫升/分钟 对比0.3 +/- 0.1，p小于0.05）方面都表现出更好的保留。我们得出结论，自由基清除剂SOD在缺血和再灌注期间为肾脏提供了显著的保护。
