Burke Shanna L, Barker Warren, Grudzien Adrienne, Greig-Custo Maria T, Behar Raquel, Rodriguez Rosemarie A, Rosselli Monica, Velez Uribe Idaly, Loewenstein David A, Rodriguez Miriam J, Chirinos Cesar, Quinonez Carlos, Gonzalez Joanna, Pineiro Yaimara Gonzalez, Herrera Mileidys, Adjouadi Malek, Marsiske Michael, Duara Ranjan
School of Social Work, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
1Florida ADRC, University of Florida, Gainesville, FL, USA.
J Appl Gerontol. 2024 Dec 10:7334648241302159. doi: 10.1177/07334648241302159.
Attrition is a significant methodological concern in longitudinal studies. Sample loss can limit generalizability and compromise internal validity. Wave one ( = 346) and wave two follow-ups ( = 196) of the 1Florida ADRC clinical core were examined using a 24-month visit window. The sample (59% Hispanic) demonstrated retention rates of 77.2% and 86.2% in waves one and two, respectively. Predictors of lower retention in wave one included older age, amnestic MCI or dementia, and lower cognition and function scores. Completing a baseline MRI and lack of hippocampal atrophy were associated with higher retention in both waves. In wave two, a greater neighborhood disadvantage score was associated with attrition. Predictors of retention changed over time, possibly due to the early withdrawal of the most vulnerable in the initial wave. Understanding predictors of retention can facilitate retention strategies, reduce attrition, and increase the validity of findings.
在纵向研究中，样本损耗是一个重要的方法学问题。样本流失会限制研究结果的可推广性并损害内部效度。使用24个月的随访窗口对佛罗里达阿尔茨海默病研究中心临床核心的第一次随访（n = 346）和第二次随访（n = 196）进行了检查。该样本（59%为西班牙裔）在第一次和第二次随访中的保留率分别为77.2%和86.2%。第一次随访中保留率较低的预测因素包括年龄较大、遗忘型轻度认知障碍或痴呆以及较低的认知和功能评分。完成基线磁共振成像和无海马萎缩与两次随访中的较高保留率相关。在第二次随访中，更大的邻里劣势得分与样本损耗相关。保留率的预测因素随时间而变化，这可能是由于最初随访中最脆弱的人群提前退出所致。了解保留率的预测因素有助于制定保留策略、减少样本损耗并提高研究结果的效度。
