孕妇孕前及孕期体重指数与儿童端粒长度之间的关联：一项系统评价与荟萃分析

Association Between Maternal Prepregnancy and Pregnancy Body Mass Index and Children's Telomere Length: A Systematic Review and Meta-analysis.

作者信息

Lame-Jouybari Amir Hossein, Fahami Mohammad Salar, Hosseini Mahla Sadat, Moradpour Maryam, Hojati Ali, Abbasalizad-Farhangi Mahdieh

机构信息

Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, 5166614711, Iran.

Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, 5166614711, Iran.

出版信息

Nutr Rev. 2025 Apr 1;83(4):622-635. doi: 10.1093/nutrit/nuae187.

DOI:10.1093/nutrit/nuae187

PMID:39658339

Abstract

CONTEXT

Telomeres maintain chromosome stability and mark cellular aging, and their shortening with age compromises genomic stability.

OBJECTIVE

The purpose of this study was to conduct a meta-analysis of existing evidence to evaluate the relationship between the maternal pregnancy body mass index (BMI) and children's telomere length (TL).

DATA SOURCE

Web of Science, Scopus, and PubMed databases were systematically searched from their inception to August 27, 2023, for pertinent observational studies.

DATA EXTRACTION

The random-effects meta-analysis was conducted on eligible studies that investigated the linear relationship between exposure and the outcomes of interest, utilizing the reported β-coefficient. Cochran's Q test and I2 statistics were used to assess heterogeneity.

DATA ANALYSIS

A significant association was observed between maternal pregnancy BMI and children's TL (32 studies, pooled effect size [ES]: -0.04; 95% CI: -0.06 to -0.01; I2 = 47.51%, P < .001) and maternal prepregnancy BMI and children's TL at birth (16 studies; pooled ES: -0.05; 95% CI: -0.08 to -0.02; I2 = 53.49%, P < .001).

CONCLUSION

The findings indicate an inverse association between maternal prepregnancy BMI and TL in infants, which is evident within the normal to obese BMI range. This underscores the significance of maternal weight status before pregnancy as a determinant of offspring TL.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO registration no. CRD42023466425.

摘要

背景

端粒维持染色体稳定性并标志细胞衰老，随着年龄增长其缩短会损害基因组稳定性。

目的

本研究旨在对现有证据进行荟萃分析，以评估孕妇孕期体重指数（BMI）与儿童端粒长度（TL）之间的关系。

数据来源

对Web of Science、Scopus和PubMed数据库从建库至2023年8月27日进行系统检索，查找相关观察性研究。

数据提取

对符合条件的研究进行随机效应荟萃分析，这些研究调查了暴露因素与感兴趣结局之间的线性关系，使用报告的β系数。采用Cochran's Q检验和I²统计量评估异质性。

数据分析

观察到孕妇孕期BMI与儿童TL之间存在显著关联（32项研究，合并效应量[ES]：-0.04；95%置信区间：-0.06至-0.01；I² = 47.51%，P <.001），以及孕妇孕前BMI与出生时儿童TL之间存在显著关联（16项研究；合并ES：-0.05；95%置信区间：-0.08至-0.02；I² = 53.49%，P <.001）。