Liu Jiani, Chen Danrong, Huang Yanqiu, Bigambo Francis Manyori, Chen Ting, Wang Xu
State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Front Public Health. 2021 Jul 8;9:648196. doi: 10.3389/fpubh.2021.648196. eCollection 2021.
Triclosan (TCS) is an environmental chemical with endocrine disrupting effects and can enter the body through the skin or oral mucosa. Human data about the effect of TCS exposure during pregnancy on neonatal birth weight and TCS exposure during childhood on children's growth are scarce. To investigate the association between maternal urinary TCS level and neonatal birth weight, as well as children's urinary TCS level and children's body mass index (BMI). A systematic literature search was conducted using PubMed, Cochrane Library, and Web of Science. Finally, seven epidemiological articles with 5,006 participants from September 25, 2014 to August 10, 2018 were included in the meta-analysis to identify the relationship between maternal exposure to TCS and neonatal birth weight. On the other hand, three epidemiological articles with 5,213 participants from July 22, 2014 to September 1, 2017 were included in another meta-analysis to identify the relationship between children's exposure to TCS and children's BMI. We used Stata 16.0 to test the heterogeneity among the studies and calculating the combined effect value 95% confidence interval (CI) of the selected corresponding models. TCS exposure during pregnancy was not significant associated with neonatal birth weight. The results of forest plots were as follows: ES (Estimate) = 0.41 (95% CI: -11.97-12.78). Children's urinary TCS level was also irrelevant associated with children's BMI: ES = 0.03 (95% CI: -0.54-0.60). This meta-analysis demonstrated that there was no significant association between maternal TCS level and neonatal birth weight, also there has no relationship between children's urinary TCS level and children's BMI.
三氯生（TCS）是一种具有内分泌干扰作用的环境化学物质，可通过皮肤或口腔黏膜进入人体。关于孕期接触TCS对新生儿出生体重的影响以及儿童期接触TCS对儿童生长发育影响的人体数据较少。本研究旨在探讨母亲尿中TCS水平与新生儿出生体重之间的关联，以及儿童尿中TCS水平与儿童体重指数（BMI）之间的关联。我们使用PubMed、Cochrane图书馆和科学网进行了系统的文献检索。最终，7篇流行病学文章（共5006名参与者，研究时间为2014年9月25日至2018年8月10日）被纳入荟萃分析，以确定母亲接触TCS与新生儿出生体重之间的关系。另一方面，3篇流行病学文章（共5213名参与者，研究时间为2014年7月22日至2017年9月1日）被纳入另一项荟萃分析，以确定儿童接触TCS与儿童BMI之间的关系。我们使用Stata 16.0检验各研究间的异质性，并计算所选相应模型的合并效应值95%置信区间（CI）。孕期接触TCS与新生儿出生体重无显著关联。森林图结果如下：效应估计值（ES）=0.41（95%CI：-11.97-12.78）。儿童尿中TCS水平与儿童BMI也无相关性：ES=0.03（95%CI：-0.54-0.60）。这项荟萃分析表明，母亲TCS水平与新生儿出生体重之间无显著关联，儿童尿中TCS水平与儿童BMI之间也无关联。
