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针对老年人抑郁症的个性化互联网认知行为疗法:一项随机对照试验。

Tailored internet-delivered cognitive behavior therapy for depression in older adults: a randomized controlled trial.

作者信息

Nordgren Lise Bergman, Ludvigsson Mikael, Silfvernagel Kristin, Törnhage Linnéa, Sävås Lisa, Söderqvist Sophie, Dinnetz Sofia, Henrichsén Paulina, Larsson Johanna, Ström Hanna, Lindh Malin, Berger Thomas, Andersson Gerhard

机构信息

Region Örebro län and Department of medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Department of Psychiatry in Linköping, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

出版信息

BMC Geriatr. 2024 Dec 10;24(1):998. doi: 10.1186/s12877-024-05597-8.

Abstract

BACKGROUND

Depression is a common and serious problem in older adults, but few have access to psychological treatments. Internet-delivered Cognitive Behavioral Therapy (ICBT) has the potential to improve access and has been found to be effective in adults with depression. The aim of this study was to examine the effects of tailored ICBT for depression in older adults aged 65 years or older. We also investigated if cognitive flexibility could predict outcome.

METHODS

Following online recruitment from the community, included participants were randomly allocated to either ten weeks of clinician guided ICBT (n = 50) or to an active control group in the form of non-directive support (n = 51). Primary depression outcome was the Geriatric Depression Scale (GDS-15). Several secondary outcomes were used, such as the Beck Depression Inventory (BDI-II) and the Patient Health Questionnaire (PHQ-9).

RESULTS

Both treatment and active control groups significantly reduced their levels of depression, and the treatment group showed significantly greater improvement on the GDS-15 and BDI-II, but not on the PHQ-9. Between-group effect sizes as Cohen's d were 0.78 (CI95% 0.36-1.20) on the GDS-15 and 0.53 (CI95% 0.11-0.94) on the BDI-II.

CONCLUSIONS

Tailored ICBT is superior to an active control for older adults with depression. Between-group effects were smaller than in previous RCTs, most likely because of the use of an active control condition. Cognitive flexibility did not predict outcome. We conclude that ICBT can be used for older adults with depression, and thus increase access to psychotherapy for this group.

TRIAL REGISTRATION

This trial was retrospectively registered in clinicaltrials.gov (no. NCT05269524) the 8th of March 2022.

摘要

背景

抑郁症在老年人中是一个常见且严重的问题,但很少有人能获得心理治疗。互联网认知行为疗法(ICBT)有可能改善治疗可及性,并且已被发现对患有抑郁症的成年人有效。本研究的目的是检验针对65岁及以上老年人抑郁症的定制ICBT的效果。我们还调查了认知灵活性是否可以预测治疗结果。

方法

在从社区进行在线招募后,纳入的参与者被随机分配到接受为期十周的临床医生指导的ICBT组(n = 50)或接受非指导性支持形式的积极对照组(n = 51)。主要抑郁症结局指标是老年抑郁量表(GDS - 15)。还使用了几个次要结局指标,如贝克抑郁量表(BDI - II)和患者健康问卷(PHQ - 9)。

结果

治疗组和积极对照组的抑郁水平均显著降低,治疗组在GDS - 15和BDI - II上显示出显著更大的改善,但在PHQ - 9上没有。组间效应量(以科恩d值表示)在GDS - 15上为0.78(CI95% 0.36 - 1.20),在BDI - II上为0.53(CI95% 0.11 - 0.94)。

结论

对于患有抑郁症的老年人,定制ICBT优于积极对照。组间效应小于先前的随机对照试验,最可能的原因是使用了积极对照条件。认知灵活性不能预测治疗结果。我们得出结论,ICBT可用于患有抑郁症的老年人,从而增加该群体获得心理治疗的机会。

试验注册

本试验于2022年3月8日在clinicaltrials.gov(编号NCT05269524)进行回顾性注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd60/11629493/786684710564/12877_2024_5597_Fig1_HTML.jpg

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