Bergsland Niels, Dwyer Michael G, Zivadinov Robert
Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.
Mult Scler. 2024 Dec;30(5_suppl):24-29. doi: 10.1177/13524585241292965.
The choroid plexus (CP), a highly vascularized structure within the ventricles of the brain, has come under increased scrutiny over the last several years as potentially having a role in the pathophysiology of multiple sclerosis (MS). Originally consider as being only responsible for the production of cerebrospinal fluid, it is now widely recognized that the CP is also involved in immunosurveillance and immune cell trafficking. Histopathology studies have found several immunological changes in donor tissue, including the accumulation of inflammatory cells. These findings have been corroborated by animal studies combining immunohistopathology and magnetic resonance imaging (MRI), showing dynamic changes in CP volume that track immune cell infiltration into the CP itself. Subsequent in vivo studies in persons with MS using MRI have suggested that while CP volume increases very early in the disease, CP inflammation continues to have a role throughout later stages as well. Together with recent advances in image processing methods, the analysis of prospective studies as well as existing datasets will help shed further light on the underlying pathophysiological changes within the CP. Such studies are needed to better understand if the CP may represent a novel therapeutic target to ultimately impact the evolution of the disease.
脉络丛（CP）是位于脑室中的高度血管化结构，在过去几年中受到了越来越多的关注，因为它可能在多发性硬化症（MS）的病理生理学中发挥作用。最初认为它仅负责脑脊液的产生，现在人们普遍认识到CP也参与免疫监视和免疫细胞运输。组织病理学研究在供体组织中发现了几种免疫学变化，包括炎症细胞的积累。这些发现已得到结合免疫组织病理学和磁共振成像（MRI）的动物研究的证实，显示CP体积的动态变化跟踪免疫细胞浸润到CP本身。随后在MS患者中使用MRI进行的体内研究表明，虽然CP体积在疾病早期就增加，但CP炎症在后期也继续发挥作用。随着图像处理方法的最新进展，对前瞻性研究以及现有数据集的分析将有助于进一步阐明CP内潜在的病理生理变化。需要进行此类研究以更好地了解CP是否可能代表一个新的治疗靶点，最终影响疾病的发展。
