研究偏头痛与帕金森病之间的因果关系和遗传关系。

Investigating the causal and genetic relationship between migraine and Parkinson's disease.

作者信息

Deng Ming-Gang, Zhou Xiuxiu, Liu Fang, Wang Kai, Luo Lingli, Zhang Min-Jie, Feng Qianqian, Liu Jiewei

机构信息

Department of Psychiatry, Wuhan Mental Health Center, Wuhan, Hubei, China.

Department of Psychiatry, Wuhan Hospital for Psychotherapy, Wuhan, Hubei, China.

出版信息

Headache. 2025 May;65(5):835-844. doi: 10.1111/head.14881. Epub 2024 Dec 10.

DOI:10.1111/head.14881

PMID:39658945

Abstract

OBJECTIVE

The relationship between migraine and Parkinson's disease (PD) remains controversial. We aimed to investigate the causal and genetic associations between migraine and PD.

METHODS

Genetic data for migraine [any migraine (AM), migraine without aura (MO), and migraine with aura (MA)] and PD were sourced from the latest genome-wide meta-analyses conducted by the International Headache Genetics Consortium and the International Parkinson's Disease Genomics Consortium, respectively. Various analyses were performed to evaluate the potential causal associations and explore genetic correlations between these conditions.

RESULTS

The analyses indicated that AM (odds ratio [OR] 1.02, 95% confidence interval [CI] 0.91-1.14; p = 0.785), MO (OR 0.94, 95% CI 0.84-1.07; p = 0.358), and MA (OR 1.01, 95% CI 0.95-1.06; p = 0.846) were not significantly associated with the risk of PD. Similarly, reverse analyses also demonstrated no significant causality between PD and the risks of migraine or its subtypes. After adjusting for coronary heart disease, AM (OR 0.99, 95% CI 0.90-1.10; p = 0.897), MO (OR 0.94, 95% CI 0.86-1.03; p = 0.207), and MA (OR 1.00, 95% CI 0.93-1.07; p = 0.902) remained unrelated to PD risk. Likewise, PD was found to be unassociated with AM (OR 0.96, 95% CI 0.92-1.02; p = 0.168), MO (OR 0.95, 95% CI 0.86-1.05; p = 0.287), and MA (OR 1.02, 95% CI 0.93-1.13; p = 0.669). These null findings persisted even when adjusting for hypertension. Apart from above causal inference results, no significant genetic correlation was found between AM (r = -0.06, p = 0.127), MA (r = -0.05, p = 0.516), or MO (r = -0.06, p = 0.492) and PD, and no correlations were observed across specific genomic regions. Additionally, no shared heritability was observed between PD and migraine, or its subtypes, in tissue expression.

CONCLUSION

Our study suggests that there is no significant causal association or genetic correlation between migraine and PD from a genetic perspective.

摘要

目的

偏头痛与帕金森病（PD）之间的关系仍存在争议。我们旨在研究偏头痛与PD之间的因果关系和遗传关联。

方法

偏头痛[任何偏头痛（AM）、无先兆偏头痛（MO）和有先兆偏头痛（MA）]和PD的遗传数据分别来自国际头痛遗传学联盟和国际帕金森病基因组学联盟进行的最新全基因组荟萃分析。进行了各种分析以评估潜在的因果关联，并探索这些疾病之间的遗传相关性。

结果

分析表明，AM（优势比[OR]1.02，95%置信区间[CI]0.91 - 1.14；p = 0.785）、MO（OR 0.94，95% CI 0.84 - 1.07；p = 0.358）和MA（OR 1.01，95% CI 0.95 - 1.06；p = 0.846）与PD风险无显著关联。同样，反向分析也表明PD与偏头痛及其亚型风险之间无显著因果关系。在调整冠心病后，AM（OR 0.99，95% CI 0.90 - 1.10；p = 0.897）、MO（OR 0.94，95% CI 0.86 - 1.03；p = 0.207）和MA（OR 1.00，95% CI 0.93 - 1.07；p = 0.902）仍与PD风险无关。同样，发现PD与AM（OR 0.96，95% CI 0.92 - 1.02；p = 0.168）、MO（OR 0.95，95% CI 0.86 - 1.05；p = 0.287）和MA（OR 1.02，95% CI 0.93 - 1.13；p = 0.669）无关。即使在调整高血压后，这些阴性结果仍然存在。除上述因果推断结果外，未发现AM（r = -0.06，p = 0.127）、MA（r = -0.05，p = 0.516）或MO（r = -0.06，p = 0.492）与PD之间存在显著遗传相关性，且在特定基因组区域未观察到相关性。此外，在组织表达中，未观察到PD与偏头痛及其亚型之间存在共享遗传力。